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Pgbd5 Gene Detail
Summary
  • Symbol
    Pgbd5
  • Name
    piggyBac transposable element derived 5
  • Synonyms
    2900019M05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429955
    NCBI Gene: 209966
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125095788-125161230 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2576 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429955
 protein coding gene Chr8:125095788-125166397 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034270
 protein coding gene Chr8:128044636-128123124 (-)
A/J MGP_AJ_G0034250
 protein coding gene Chr8:122751376-122823753 (-)
AKR/J MGP_AKRJ_G0034177
 protein coding gene Chr8:126277547-126351175 (-)
BALB/cJ MGP_BALBcJ_G0034243
 protein coding gene Chr8:122934862-123008601 (-)
C3H/HeJ MGP_C3HHeJ_G0033954
 protein coding gene Chr8:126916537-126991384 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034763
 protein coding gene Chr8:132338578-132413463 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031704
 protein coding gene Chr8:115523085-115592267 (-)
CAST/EiJ MGP_CASTEiJ_G0033281
 protein coding gene Chr8:127033440-127107723 (-)
CBA/J MGP_CBAJ_G0033927
 protein coding gene Chr8:137175670-137257515 (-)
DBA/2J MGP_DBA2J_G0034083
 protein coding gene Chr8:121909037-121979576 (-)
FVB/NJ MGP_FVBNJ_G0034027
 protein coding gene Chr8:121073924-121149986 (-)
LP/J MGP_LPJ_G0034172
 protein coding gene Chr8:128200754-128281916 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034074
 protein coding gene Chr8:139281656-139358737 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034782
 protein coding gene Chr8:126514108-126589569 (-)
PWK/PhJ MGP_PWKPhJ_G0032983
 protein coding gene Chr8:121667471-121741469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032822
 protein coding gene Chr8:125158248-125229676 (-)
WSB/EiJ MGP_WSBEiJ_G0033398
 protein coding gene Chr8:127237861-127314140 (-)



Homology
more
  • Human Ortholog
    PGBD5, piggyBac transposable element derived 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGBD5, piggyBac transposable element derived 5
  • Links
    NCBI Gene ID: 79605
    neXtProt AC: NX_Q8N414
    UniProt: Q8N414

  • Chr Location
    1q42.13; chr1:230314490-230426332 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display normal cerebellar development and, in the context of medulloblastoma models, reduced tumor formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    10
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 209966 NCBI Gene Model | MGI Sequence Detail 65443 C57BL/6J ±  kb
    transcript NM_171824 RefSeq | MGI Sequence Detail 3379 C57BL/6  
    polypeptide D3YZI9 UniProt | EBI | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012601 piggyBac transposable element-derived protein 5
      (term hierarchy)
    • EC
      3.1.-.-
    • InterPro Domains
      IPR029526 PiggyBac transposable element-derived protein
      IPR042423 PiggyBac transposable element-derived protein 5
    • GlyGen
      D3YZI9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 16

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914507, MGI:2142643
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:80162 Bonaldo MF, et al., Normalization and subtraction: two approaches to facilitate gene discovery. Genome Res. 1996 Sep;6(9):791-806
    • Latest
      J:346387 Yamada M, et al., Childhood cancer mutagenesis caused by transposase-derived PGBD5. Sci Adv. 2024 Mar 22;10(12):eadn4649
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory