Dnhd1 MGI Mouse Gene Detail - MGI:1924755 - dynein heavy chain domain 1

Symbol

Dnhd1
Name

dynein heavy chain domain 1
Synonyms

8030491N06Rik

Feature Type

protein coding gene
IDs

MGI:1924755
NCBI Gene: 77505
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:105300034-105371006 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 55.93 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

1306 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924755	protein coding gene	Chr7:105299983-105371007 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032760	protein coding gene	Chr7:108903663-108989677 (+)
A/J	MGP_AJ_G0032740	protein coding gene	Chr7:106050452-106136878 (+)
AKR/J	MGP_AKRJ_G0032673	protein coding gene	Chr7:108824605-108907093 (+)
BALB/cJ	MGP_BALBcJ_G0032746	protein coding gene	Chr7:105766980-105850539 (+)
C3H/HeJ	MGP_C3HHeJ_G0032455	protein coding gene	Chr7:108932260-109013491 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033251	protein coding gene	Chr7:113263908-113349311 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030235	protein coding gene	Chr7:108029211-108108811 (+)
CAST/EiJ	MGP_CASTEiJ_G0031785	protein coding gene	Chr7:100758938-100840361 (+)
CBA/J	MGP_CBAJ_G0032429	protein coding gene	Chr7:117027381-117123746 (+)
DBA/2J	MGP_DBA2J_G0032582	protein coding gene	Chr7:104320068-104401775 (+)
FVB/NJ	MGP_FVBNJ_G0032535	protein coding gene	Chr7:104129076-104209138 (+)
LP/J	MGP_LPJ_G0032673	protein coding gene	Chr7:110307223-110394271 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032567	protein coding gene	Chr7:118613779-118701627 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033272	protein coding gene	Chr7:107891826-107978552 (+)
PWK/PhJ	MGP_PWKPhJ_G0031498	protein coding gene	Chr7:97260310-97342498 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031347	protein coding gene	Chr7:95002305-95088935 (+)
WSB/EiJ	MGP_WSBEiJ_G0031902	protein coding gene	Chr7:108534351-108615649 (+)

Human Ortholog

DNHD1, dynein heavy chain domain 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNHD1, dynein heavy chain domain 1
Synonyms

C11orf47, CCDC35, DHCD1, DNHD1L, SPGF65
Links

HGNC:26532

NCBI Gene ID: 144132

neXtProt AC: NX_Q96M86

UniProt: Q96M86
Chr Location

11p15.4; chr11:6497260-6593758 (+) GRCh38

MGI Vertebrate Homology

Dnhd1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DNHD1
Gene Tree

Dnhd1

Diseases

1 with human DNHD1 associations

				Human Disease	Mouse Models
				spermatogenic failure 65 IDs spermatogenic failure 65 DOID:0112354 OMIM:619712

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Dnhd1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

196 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Males homozygous for a null allele exhibit male infertility, reduced sperm numbers and sperm motility, and abnormalities of sperm flagella.

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

7
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

3

Ensembl

ENSMUSG00000030882 (Evidence)
NCBI Gene

77505

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030882	Ensembl Gene Model \| MGI Sequence Detail	70973	C57BL/6J	± kb
transcript	ENSMUST00000145988	Ensembl \| MGI Sequence Detail	14536	Not Applicable
polypeptide	ENSMUSP00000121261	Ensembl \| MGI Sequence Detail	4750	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032005 dynein heavy chain domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR026983 Dynein heavy chain

IPR041466 Dynein heavy chain, AAA 5 extension domain

IPR024317 Dynein heavy chain, AAA module D4

IPR024743 Dynein heavy chain, coiled coil stalk

IPR041228 Dynein heavy chain, C-terminal domain

IPR043160 Dynein heavy chain, C-terminal domain, barrel region

IPR042222 Dynein heavy chain, domain 2, N-terminal

IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region

IPR013602 Dynein heavy chain, linker

IPR042228 Dynein heavy chain, linker, subdomain 3

IPR004273 Dynein heavy chain region D6 P-loop domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 14

Genomic 2

cDNA 12

Microarray probesets 1

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 17
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnhd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68390	Chr7:105299976-105300005 (+)	-43 bp
Tssr68391	Chr7:105300020-105300040 (+)	-4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24