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Piezo1 Gene Detail
Summary
  • Symbol
    Piezo1
  • Name
    piezo-type mechanosensitive ion channel component 1
  • Synonyms
    Fam38a, Piezo1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3603204
    NCBI Gene: 234839
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123208437-123278068 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 71.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2043 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3603204
 protein coding gene Chr8:123208437-123278068 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034229
 protein coding gene Chr8:126024529-126099280 (-)
A/J MGP_AJ_G0034209
 protein coding gene Chr8:120806488-120877561 (-)
AKR/J MGP_AKRJ_G0034136
 protein coding gene Chr8:124324986-124399367 (-)
BALB/cJ MGP_BALBcJ_G0034203
 protein coding gene Chr8:121007477-121077989 (-)
C3H/HeJ MGP_C3HHeJ_G0033914
 protein coding gene Chr8:125023250-125095671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034723
 protein coding gene Chr8:130224980-130308958 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031665
 protein coding gene Chr8:113641274-113714746 (-)
CAST/EiJ MGP_CASTEiJ_G0033241
 protein coding gene Chr8:125103974-125177885 (-)
CBA/J MGP_CBAJ_G0033887
 protein coding gene Chr8:135016850-135095527 (-)
DBA/2J MGP_DBA2J_G0034043
 protein coding gene Chr8:119997436-120067712 (-)
FVB/NJ MGP_FVBNJ_G0033986
 protein coding gene Chr8:119141097-119214244 (-)
LP/J MGP_LPJ_G0034132
 protein coding gene Chr8:126148246-126221333 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034033
 protein coding gene Chr8:137192346-137266185 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034741
 protein coding gene Chr8:124508570-124582040 (-)
PWK/PhJ MGP_PWKPhJ_G0032943
 protein coding gene Chr8:119818531-119889942 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032783
 protein coding gene Chr8:123233146-123307780 (-)
WSB/EiJ MGP_WSBEiJ_G0033357
 protein coding gene Chr8:125265980-125337521 (-)



Homology
more
  • Human Ortholog
    PIEZO1, piezo type mechanosensitive ion channel component 1 (Er blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIEZO1, piezo type mechanosensitive ion channel component 1 (Er blood group)
  • Synonyms
    DHS, ER, FAM38A, LMPH3, LMPHM6, Mib
  • Links
    NCBI Gene ID: 9780
    neXtProt AC: NX_Q92508
    UniProt: Q92508

  • Chr Location
    16q24.3; chr16:88715338-88785220 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PIEZO1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 5 alleles in 5 genetic backgrounds
    3 images
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mice homozygous for a gene trapped allele die at midgestation, exhibiting embryonic growth retardation, pericardial effusion, and vascular remodeling defects in the yolk sac and the embryo proper.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    45
  • cDNA Data
    9
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234839 NCBI Gene Model | MGI Sequence Detail 69632 C57BL/6J ±  kb
    transcript NM_001357349 RefSeq | MGI Sequence Detail 8219 C57BL/6  
    polypeptide E2JF22 UniProt | EBI | MGI Sequence Detail 2547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 10
      Gene Ontology 15
      Phenotypes 90
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:354312 Hurrell BP, et al., Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity. J Exp Med. 2024 May 6;221(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory