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Fam170b Gene Detail
Summary
  • Symbol
    Fam170b
  • Name
    family with sequence similarity 170, member B
  • Synonyms
    4922501K12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145650
    NCBI Gene: 105511
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:32555938-32558746 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145650
 protein coding gene Chr14:32555919-32558746 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021151
 protein coding gene Chr14:26103061-26105888 (+)
A/J MGP_AJ_G0021099
 protein coding gene Chr14:25105474-25108301 (+)
AKR/J MGP_AKRJ_G0021076
 protein coding gene Chr14:26259882-26262709 (+)
BALB/cJ MGP_BALBcJ_G0021103
 protein coding gene Chr14:25286287-25289114 (+)
C3H/HeJ MGP_C3HHeJ_G0020886
 protein coding gene Chr14:26139944-26142771 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021535
 protein coding gene Chr14:27130144-27132971 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019097
 protein coding gene Chr14:25163661-25166520 (+)
CAST/EiJ MGP_CASTEiJ_G0020411
 protein coding gene Chr14:25955006-25957808 (+)
CBA/J MGP_CBAJ_G0020853
 protein coding gene Chr14:28150076-28152903 (+)
DBA/2J MGP_DBA2J_G0020975
 protein coding gene Chr14:25158309-25161131 (+)
FVB/NJ MGP_FVBNJ_G0020959
 protein coding gene Chr14:25098438-25101265 (+)
LP/J MGP_LPJ_G0021044
 protein coding gene Chr14:26423213-26426040 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020985
 protein coding gene Chr14:27340073-27342900 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021568
 protein coding gene Chr14:26058521-26061348 (+)
PWK/PhJ MGP_PWKPhJ_G0020159
 protein coding gene Chr14:24619317-24622078 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019983
 protein coding gene Chr14:25681530-25684319 (+)
WSB/EiJ MGP_WSBEiJ_G0020466
 protein coding gene Chr14:26127687-26130509 (+)



Homology
more
  • Human Ortholog
    FAM170B, family with sequence similarity 170 member B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM170B, family with sequence similarity 170 member B
  • Synonyms
    C10orf73
  • Links
    NCBI Gene ID: 170370
    neXtProt AC: NX_A6NMN3
    UniProt: A6NMN3

  • Chr Location
    10q11.23
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    3 phenotype references
Male mice homozygous for a null allele exhibit reduced fertility with oligozoospermia and abnormal spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 105511 NCBI Gene Model | MGI Sequence Detail 2809 C57BL/6J ±  kb
transcript NM_001164485 RefSeq | MGI Sequence Detail 1675 C57BL/6  
polypeptide E9PXT9 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:293721 Devlin DJ, et al., Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice. Biol Reprod. 2020 Aug 4;103(2):205-222
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory