Parp4 MGI Mouse Gene Detail - MGI:2685589 - poly (ADP-ribose) polymerase family, member 4

Symbol

Parp4
Name

poly (ADP-ribose) polymerase family, member 4
Synonyms

Adprtl1, C030027K23Rik, E230037B21Rik, p193, PH5P, VAULT3, VPARP

Feature Type

protein coding gene
IDs

MGI:2685589
NCBI Gene: 328417
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr14:56813076-56897251 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.31 cM
Mapping Data

2 experiments

SNPs within 2kb

2165 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685589	protein coding gene	Chr14:56812982-56897256 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021395	protein coding gene	Chr14:50666894-50753488 (+)
A/J	MGP_AJ_G0021354	protein coding gene	Chr14:49660452-49744615 (+)
AKR/J	MGP_AKRJ_G0021330	protein coding gene	Chr14:51459604-51544875 (+)
BALB/cJ	MGP_BALBcJ_G0021357	protein coding gene	Chr14:49651275-49735316 (+)
C3H/HeJ	MGP_C3HHeJ_G0021138	protein coding gene	Chr14:51103638-51188751 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021797	protein coding gene	Chr14:53196763-53282781 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019339	protein coding gene	Chr14:47815812-47902733 (+)
CAST/EiJ	MGP_CASTEiJ_G0020657	protein coding gene	Chr14:47426273-47513148 (+)
CBA/J	MGP_CBAJ_G0021105	protein coding gene	Chr14:54776526-54864140 (+)
DBA/2J	MGP_DBA2J_G0021225	protein coding gene	Chr14:49376975-49461189 (+)
FVB/NJ	MGP_FVBNJ_G0021208	protein coding gene	Chr14:48765565-48854384 (+)
LP/J	MGP_LPJ_G0021300	protein coding gene	Chr14:51735787-51823752 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021232	protein coding gene	Chr14:54170492-54258195 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021823	protein coding gene	Chr14:50588276-50679902 (+)
PWK/PhJ	MGP_PWKPhJ_G0020400	protein coding gene	Chr14:45897102-45983264 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020230	protein coding gene	Chr14:46655478-46743101 (+)
WSB/EiJ	MGP_WSBEiJ_G0020709	protein coding gene	Chr14:50925869-51016829 (+)

Human Ortholog

PARP4, poly(ADP-ribose) polymerase family member 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARP4, poly(ADP-ribose) polymerase family member 4
Synonyms

ADPRTL1, ARTD4, p193, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C
Links

HGNC:271

NCBI Gene ID: 143

neXtProt AC: NX_Q9UKK3

UniProt: Q9UKK3
Chr Location

13q12.12; chr13:24420931-24512778 (-) GRCh38

MGI Vertebrate Homology

Parp4 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: PARP4
Gene Tree

Parp4

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

13
Targeted

1
Genomic Mutations

1 involving Parp4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

90 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants are helathy and fertile.

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

7
cDNA Data

23
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase parp4.1

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All Sequences

39
RefSeq

7
UniProt

1
CCDS

CCDS49503.1

Ensembl

ENSMUSG00000054509 (Evidence)
NCBI Gene

328417

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054509	Ensembl Gene Model \| MGI Sequence Detail	84176	C57BL/6J	± kb
transcript	ENSMUST00000161553	Ensembl \| MGI Sequence Detail	6387	Not Applicable
polypeptide	ENSMUSP00000124258	Ensembl \| MGI Sequence Detail	1969	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012298 protein mono-ADP-ribosyltransferase PARP4

(term hierarchy)
EC

2.4.2.-
InterPro Domains

IPR001357 BRCT domain

IPR036420 BRCT domain superfamily

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain

IPR004102 Poly(ADP-ribose) polymerase, regulatory domain

IPR036616 Poly(ADP-ribose) polymerase, regulatory domain superfamily

IPR031273 Protein mono-ADP-ribosyltransferase PARP4

IPR013694 VIT domain

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A
GlyGen

E9PYK3 1 site, 1 O-linked glycan (1 site)

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 2

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MGI:1924669

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Parp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125837	Chr14:56812966-56812991 (+)	-97 bp
Tssr125838	Chr14:56812994-56813003 (+)	-77 bp
Tssr125839	Chr14:56813060-56813090 (+)	-1 bp
Tssr4440	Chr14:56813093-56813096 (+)	19 bp
Tssr125840	Chr14:56813097-56813122 (+)	34 bp
Tssr125841	Chr14:56858370-56858375 (+)	45,297 bp
Tssr125842	Chr14:56884952-56884994 (+)	71,897 bp
Tssr125843	Chr14:56885049-56885062 (+)	71,980 bp
Tssr125844	Chr14:56885144-56885164 (+)	72,078 bp
Tssr125845	Chr14:56885256-56885260 (+)	72,182 bp
Tssr125846	Chr14:56885534-56885559 (+)	72,471 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24