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Rnf213 Gene Detail
Summary
  • Symbol
    Rnf213
  • Name
    ring finger protein 213
  • Synonyms
    D11Ertd759e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289196
    NCBI Gene: 672511
  • Alliance
    gene page
  • Transcription Start Sites
    47 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119283926-119378244 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2031 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289196
 protein coding gene Chr11:119280778-119378245 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019482
 protein coding gene Chr11:123791042-123893548 (+)
A/J MGP_AJ_G0019450
 protein coding gene Chr11:118291192-118390652 (+)
AKR/J MGP_AKRJ_G0019420
 protein coding gene Chr11:121854494-121953499 (+)
BALB/cJ MGP_BALBcJ_G0019425
 protein coding gene Chr11:118649549-118747833 (+)
C3H/HeJ MGP_C3HHeJ_G0019231
 protein coding gene Chr11:122171728-122279446 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019874
 protein coding gene Chr11:127549596-127657623 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017499
 protein coding gene Chr11:115283162-115386360 (+)
CAST/EiJ MGP_CASTEiJ_G0018785
 protein coding gene Chr11:123645335-123751472 (+)
CBA/J MGP_CBAJ_G0019202
 protein coding gene Chr11:132501763-132635207 (+)
DBA/2J MGP_DBA2J_G0019314
 protein coding gene Chr11:117662004-117761254 (+)
FVB/NJ MGP_FVBNJ_G0019306
 protein coding gene Chr11:117334160-117437647 (+)
LP/J MGP_LPJ_G0019386
 protein coding gene Chr11:124105494-124210587 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019339
 protein coding gene Chr11:131437810-131541512 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019913
 protein coding gene Chr11:122532826-122636131 (+)
PWK/PhJ MGP_PWKPhJ_G0018551
 protein coding gene Chr11:119071477-119170165 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018343
 protein coding gene Chr11:122293145-122396553 (+)
WSB/EiJ MGP_WSBEiJ_G0018837
 protein coding gene Chr11:122518233-122624928 (+)



Homology
more
  • Human Ortholog
    RNF213, ring finger protein 213
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF213, ring finger protein 213
  • Synonyms
    ALO17, C17orf27, KIAA1618, MYMY2, MYSTR, NET57
  • Links
    NCBI Gene ID: 57674
    neXtProt AC: NX_Q63HN8
    UniProt: Q63HN8

  • Chr Location
    17q25.3
Human Diseases
more
  • Diseases
    1 with human RNF213 associations

Human Disease Mouse Models
      
IDs
 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight and circulating glucose level but normal glucose tolerance, insulin sensitivity, insulin plasma levels and leptin plasma levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    6
  • cDNA Data
    39
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      58
    • RefSeq
      12
    • UniProt
      9
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070327 Ensembl Gene Model | MGI Sequence Detail 94319 C57BL/6J ±  kb
    transcript ENSMUST00000093902 Ensembl | MGI Sequence Detail 16716 Not Applicable  
    polypeptide ENSMUSP00000091429 Ensembl | MGI Sequence Detail 5152 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 39
      Primer pair 2

      Microarray probesets 16
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:342279 Li S, et al., Knockout of Rnf213 Ameliorates Cerebral Ischemic-reperfusion Injury by Inhibiting Neuronal Apoptosis Through the Akt/GSK-3beta/beta-catenin/Bcl-2 Pathway. Neuroscience. 2023 Sep 29;533:10-21
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory