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Ccdc141 Gene Detail
Summary
  • Symbol
    Ccdc141
  • Name
    coiled-coil domain containing 141
  • Synonyms
    2610301F02Rik, CAMDI, ENSMUSG00000075261
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919735
    NCBI Gene: 545428
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:76840246-77000980 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 45.38 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919735
 protein coding gene Chr2:76840246-77006424 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025871
 protein coding gene Chr2:77420218-77591859 (-)
A/J MGP_AJ_G0025848
 protein coding gene Chr2:74417633-74586153 (-)
AKR/J MGP_AKRJ_G0025817
 protein coding gene Chr2:76412643-76578257 (-)
BALB/cJ MGP_BALBcJ_G0025843
 protein coding gene Chr2:74591610-74756130 (-)
C3H/HeJ MGP_C3HHeJ_G0025603
 protein coding gene Chr2:76619400-76786398 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026290
 protein coding gene Chr2:79708657-79882966 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023693
 protein coding gene Chr2:71813463-71974749 (-)
CAST/EiJ MGP_CASTEiJ_G0025065
 protein coding gene Chr2:76958768-77131421 (-)
CBA/J MGP_CBAJ_G0025584
 protein coding gene Chr2:82657290-82831948 (-)
DBA/2J MGP_DBA2J_G0025715
 protein coding gene Chr2:74006413-74167146 (-)
FVB/NJ MGP_FVBNJ_G0025677
 protein coding gene Chr2:73393647-73557314 (-)
LP/J MGP_LPJ_G0025803
 protein coding gene Chr2:77310711-77477476 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025708
 protein coding gene Chr2:84465776-84654557 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026346
 protein coding gene Chr2:76536535-76706714 (-)
PWK/PhJ MGP_PWKPhJ_G0024808
 protein coding gene Chr2:73966154-74134630 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024614
 protein coding gene Chr2:76786720-76950054 (-)
WSB/EiJ MGP_WSBEiJ_G0025134
 protein coding gene Chr2:77006629-77174781 (-)



Homology
more
  • Human Ortholog
    CCDC141, coiled-coil domain containing 141
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC141, coiled-coil domain containing 141
  • Synonyms
    CAMDI
  • Links
    NCBI Gene ID: 285025
    neXtProt AC: NX_Q6ZP82
    UniProt: Q6ZP82

  • Chr Location
    2q31.2; chr2:178814978-179050137 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout impairs migration of neurons in the somatosensory cortex, resulting in increased anxiety and hyperactivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    33
  • cDNA Data
    32
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044033 Ensembl Gene Model | MGI Sequence Detail 160735 C57BL/6J ±  kb
transcript ENSMUST00000164114 Ensembl | MGI Sequence Detail 6222 Not Applicable  
polypeptide ENSMUSP00000128736 Ensembl | MGI Sequence Detail 1531 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 32
    Other 1

    Microarray probesets 12
Other
Accession IDs
less
MGI:3708658
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory