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Rap1gds1 Gene Detail
Summary
  • Symbol
    Rap1gds1
  • Name
    RAP1, GTP-GDP dissociation stimulator 1
  • Synonyms
    GDS1, MGC:18981
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385189
    NCBI Gene: 229877
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:138631663-138780962 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 64.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4842 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385189
 protein coding gene Chr3:138631662-138781163 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027935
 protein coding gene Chr3:142003467-142169147 (-)
A/J MGP_AJ_G0027892
 protein coding gene Chr3:136972602-137123183 (-)
AKR/J MGP_AKRJ_G0027858
 protein coding gene Chr3:140621733-140770503 (-)
BALB/cJ MGP_BALBcJ_G0027904
 protein coding gene Chr3:136783852-136933894 (-)
C3H/HeJ MGP_C3HHeJ_G0027634
 protein coding gene Chr3:140949987-141103987 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028348
 protein coding gene Chr3:146900687-147057184 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025686
 protein coding gene Chr3:132386002-132537655 (-)
CAST/EiJ MGP_CASTEiJ_G0027090
 protein coding gene Chr3:140749129-140905232 (-)
CBA/J MGP_CBAJ_G0027611
 protein coding gene Chr3:151893339-152060786 (-)
DBA/2J MGP_DBA2J_G0027750
 protein coding gene Chr3:136097070-136245620 (-)
FVB/NJ MGP_FVBNJ_G0027717
 protein coding gene Chr3:133557301-133712556 (-)
LP/J MGP_LPJ_G0027860
 protein coding gene Chr3:143395627-143562004 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027749
 protein coding gene Chr3:159982296-160141057 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028406
 protein coding gene Chr3:140166828-140324859 (-)
PWK/PhJ MGP_PWKPhJ_G0026814
 protein coding gene Chr3:135880923-136034373 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026641
 protein coding gene Chr3:138291348-138441413 (-)
WSB/EiJ MGP_WSBEiJ_G0027169
 protein coding gene Chr3:141023035-141179680 (-)



Homology
more
  • Human Ortholog
    RAP1GDS1, Rap1 GTPase-GDP dissociation stimulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAP1GDS1, Rap1 GTPase-GDP dissociation stimulator 1
  • Synonyms
    GDS1, SmgGDS
  • Links
    NCBI Gene ID: 5910
    neXtProt AC: NX_P52306
    UniProt: P52306

  • Chr Location
    4q23; chr4:98261384-98443858 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About 70% of homozygotes for a knock-out mutation die of heart failure shortly after birth due to massive cardiomyocyte apoptosis triggered by cardiovascular overload. Neonatal thymocytes and developing neuronal cells undergo apoptosis while cultured thymocytes are susceptible to apoptotic inducers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    23
  • cDNA Data
    130
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028149 Ensembl Gene Model | MGI Sequence Detail 149300 C57BL/6J ±  kb
    transcript ENSMUST00000098574 Ensembl | MGI Sequence Detail 3669 Not Applicable  
    polypeptide ENSMUSP00000096173 Ensembl | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 132
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:62244 Takakura A, et al., Involvement of a small GTP-binding protein (G protein) regulator, small G protein GDP dissociation stimulator, in antiapoptotic cell survival signaling. Mol Biol Cell. 2000 May;11(5):1875-86
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/05/2024
    MGI 6.24     		The Jackson Laboratory