Sec16a MGI Mouse Gene Detail - MGI:2139207 - SEC16 homolog A, endoplasmic reticulum export factor

Symbol

Sec16a
Name

SEC16 homolog A, endoplasmic reticulum export factor
Synonyms

C230052J16Rik

Feature Type

protein coding gene
IDs

MGI:2139207
NCBI Gene: 227648
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:26299443-26335228 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 18.89 cM
Mapping Data

2 experiments

SNPs within 2kb

616 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2139207	protein coding gene	Chr2:26299443-26336138 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025489	protein coding gene	Chr2:24360382-24399671 (-)
A/J	MGP_AJ_G0025466	protein coding gene	Chr2:23426647-23462416 (-)
AKR/J	MGP_AKRJ_G0025436	protein coding gene	Chr2:24189745-24227219 (-)
BALB/cJ	MGP_BALBcJ_G0025462	protein coding gene	Chr2:23535639-23572155 (-)
C3H/HeJ	MGP_C3HHeJ_G0025223	protein coding gene	Chr2:24148574-24185344 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025906	protein coding gene	Chr2:25143819-25182764 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023317	protein coding gene	Chr2:22306970-22344193 (-)
CAST/EiJ	MGP_CASTEiJ_G0024686	protein coding gene	Chr2:24021949-24062037 (-)
CBA/J	MGP_CBAJ_G0025201	protein coding gene	Chr2:25996800-26037179 (-)
DBA/2J	MGP_DBA2J_G0025334	protein coding gene	Chr2:23248351-23283899 (-)
FVB/NJ	MGP_FVBNJ_G0025296	protein coding gene	Chr2:23000001-23036140 (-)
LP/J	MGP_LPJ_G0025420	protein coding gene	Chr2:24303644-24343188 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025327	protein coding gene	Chr2:26146846-26185182 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025965	protein coding gene	Chr2:24148169-24185304 (-)
PWK/PhJ	MGP_PWKPhJ_G0024434	protein coding gene	Chr2:23051955-23088910 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024234	protein coding gene	Chr2:24280965-24318453 (-)
WSB/EiJ	MGP_WSBEiJ_G0024755	protein coding gene	Chr2:24254469-24291112 (-)

Human Ortholog

SEC16A, SEC16 homolog A, endoplasmic reticulum export factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEC16A, SEC16 homolog A, endoplasmic reticulum export factor
Synonyms

KIAA0310, p250, SEC16L
Links

HGNC:29006

NCBI Gene ID: 9919

neXtProt AC: NX_O15027

UniProt: O15027
Chr Location

9q34.3; chr9:136440096-136484740 (-) GRCh38

MGI Vertebrate Homology

Sec16a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SEC16A
Gene Tree

Sec16a

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

2
Gene trapped

18
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

107 strains or lines available

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All GO Annotations

34
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

1
cDNA Data

211
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sec16a

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All Sequences

83
RefSeq

18
UniProt

7
CCDS

CCDS38085.1

Ensembl

ENSMUSG00000026924 (Evidence)
NCBI Gene

227648

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026924	Ensembl Gene Model \| MGI Sequence Detail	35786	C57BL/6J	± kb
transcript	ENSMUST00000114082	Ensembl \| MGI Sequence Detail	8797	Not Applicable
polypeptide	ENSMUSP00000109716	Ensembl \| MGI Sequence Detail	2377	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000014581 protein transport protein Sec16A

(term hierarchy)
InterPro Domains

IPR024298 Ancestral coatomer element 1, Sec16/Sec31

IPR024880 COPII coat assembly protein, Sec16

IPR024340 Sec16, central conserved domain
GlyGen

E9QAT4 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 211

cDNA 211

Microarray probesets 4

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MGI:2443275

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:302618 Wang B, et al., The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy. 2018;14(5):796-811

TSS for Sec16a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23113	Chr2:26335892-26335908 (-)	-672 bp
Tssr23112	Chr2:26335849-26335864 (-)	-629 bp
Tssr23111	Chr2:26335187-26335238 (-)	15 bp
Tssr23110	Chr2:26335122-26335128 (-)	103 bp
Tssr23109	Chr2:26330980-26330983 (-)	4,246 bp
Tssr23108	Chr2:26328647-26328652 (-)	6,578 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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