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Myo10 Gene Detail
Summary
  • Symbol
    Myo10
  • Name
    myosin X
  • Synonyms
    D15Ertd600e, mKIAA0799, myosin-X
  • Feature Type
    protein coding gene
  • IDs
    MGI:107716
    NCBI Gene: 17909
  • Alliance
    gene page
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:25622636-25813759 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 9.36 cM, cytoband C
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6363 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107716
 protein coding gene Chr15:25622611-25813759 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021750
 protein coding gene Chr15:23616159-23819000 (+)
A/J MGP_AJ_G0021710
 protein coding gene Chr15:22729132-22921260 (+)
AKR/J MGP_AKRJ_G0021688
 protein coding gene Chr15:23223432-23423540 (+)
BALB/cJ MGP_BALBcJ_G0021717
 protein coding gene Chr15:22710186-22902033 (+)
C3H/HeJ MGP_C3HHeJ_G0021493
 protein coding gene Chr15:23266227-23468222 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022156
 protein coding gene Chr15:24646813-24847577 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019696
 protein coding gene Chr15:21040500-21234057 (+)
CAST/EiJ MGP_CASTEiJ_G0021009
 protein coding gene Chr15:23612338-23828028 (+)
CBA/J MGP_CBAJ_G0021462
 protein coding gene Chr15:25438921-25645646 (+)
DBA/2J MGP_DBA2J_G0021586
 protein coding gene Chr15:22494325-22691104 (+)
FVB/NJ MGP_FVBNJ_G0021564
 protein coding gene Chr15:22055980-22249242 (+)
LP/J MGP_LPJ_G0021654
 protein coding gene Chr15:23490567-23681581 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021589
 protein coding gene Chr15:28134080-28340158 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022179
 protein coding gene Chr15:23424240-23620529 (+)
PWK/PhJ MGP_PWKPhJ_G0020752
 protein coding gene Chr15:22632455-22830063 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020590
 protein coding gene Chr15:23229693-23434246 (+)
WSB/EiJ MGP_WSBEiJ_G0021065
 protein coding gene Chr15:23423599-23623679 (+)



Homology
more
  • Human Ortholog
    MYO10, myosin X
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO10, myosin X
  • Synonyms
    MyoX
  • Links
    NCBI Gene ID: 4651
    neXtProt AC: NX_Q9HD67
    UniProt: Q9HD67

  • Chr Location
    5p15.1; chr5:16661907-16936288 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 5 alleles in 6 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1051
  • Tissues
    101
  • cDNA Data
    18
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17909 NCBI Gene Model | MGI Sequence Detail 191124 C57BL/6J ±  kb
    transcript NM_019472 RefSeq | MGI Sequence Detail 8098 ZRU/MplStud  
    polypeptide F8VQB6 UniProt | EBI | MGI Sequence Detail 2062 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 20
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36292, MGI:1277228, MGI:2146179
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 37
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345637 Yim YI, et al., Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity. Mol Biol Cell. 2024 Feb 1;35(2):ar14
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory