Trim55 MGI Mouse Gene Detail - MGI:3036269 - tripartite motif-containing 55

Symbol

Trim55
Name

tripartite motif-containing 55
Synonyms

D830041C10Rik, Murf2

Feature Type

protein coding gene
IDs

MGI:3036269
NCBI Gene: 381485
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr3:19698638-19746585 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 5.65 cM
Mapping Data

2 experiments

SNPs within 2kb

1719 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3036269	protein coding gene	Chr3:19698591-19746748 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027095	protein coding gene	Chr3:16849470-16894170 (+)
A/J	MGP_AJ_G0027055	protein coding gene	Chr3:16766680-16819881 (+)
AKR/J	MGP_AKRJ_G0027024	protein coding gene	Chr3:16924260-16984609 (+)
BALB/cJ	MGP_BALBcJ_G0027067	protein coding gene	Chr3:16528482-16575154 (+)
C3H/HeJ	MGP_C3HHeJ_G0026808	protein coding gene	Chr3:16955840-17004938 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027512	protein coding gene	Chr3:17933000-17980300 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024874	protein coding gene	Chr3:14848247-14896966 (+)
CAST/EiJ	MGP_CASTEiJ_G0026263	protein coding gene	Chr3:16871401-16916562 (+)
CBA/J	MGP_CBAJ_G0026786	protein coding gene	Chr3:18305240-18355361 (+)
DBA/2J	MGP_DBA2J_G0026920	protein coding gene	Chr3:16381061-16427280 (+)
FVB/NJ	MGP_FVBNJ_G0026888	protein coding gene	Chr3:16039055-16083355 (+)
LP/J	MGP_LPJ_G0027032	protein coding gene	Chr3:17497695-17546157 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026909	protein coding gene	Chr3:20385228-20434681 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027571	protein coding gene	Chr3:16688339-16731910 (+)
PWK/PhJ	MGP_PWKPhJ_G0025996	protein coding gene	Chr3:16094170-16140323 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025804	protein coding gene	Chr3:16543329-16587648 (+)
WSB/EiJ	MGP_WSBEiJ_G0026336	protein coding gene	Chr3:16740992-16783965 (+)

Human Ortholog

TRIM55, tripartite motif containing 55

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM55, tripartite motif containing 55
Synonyms

muRF2, MURF-2, RNF29
Links

HGNC:14215

NCBI Gene ID: 84675

neXtProt AC: NX_Q9BYV6

UniProt: Q9BYV6
Chr Location

8q13.1; chr8:66113351-66175485 (+) GRCh38

MGI Vertebrate Homology

Trim55 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TRIM55
Gene Tree

Trim55

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 3 alleles in 2 genetic backgrounds
25 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

1 involving Trim55
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased heart and muscle to body weight ratios and cardiac hypertrophy. Homozygous mice exhibit reduced severity of symptoms following SARS coronavirus infection.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

12
cDNA Data

3
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim55

ZFIN trim55a, trim55b

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All Sequences

34
RefSeq

7
UniProt

3
CCDS

CCDS38399.1

Ensembl

ENSMUSG00000060913 (Evidence)
NCBI Gene

381485

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060913	Ensembl Gene Model \| MGI Sequence Detail	47948	C57BL/6J	± kb
transcript	ENSMUST00000029139	Ensembl \| MGI Sequence Detail	2595	Not Applicable
polypeptide	ENSMUSP00000029139	Ensembl \| MGI Sequence Detail	545	Not Applicable

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UniProt

3 Sequences
EC

2.3.2.27
InterPro Domains

IPR000315 B-box-type zinc finger

IPR017903 COS domain

IPR050143 Tripartite motif-containing

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR027370 Zinc finger, RING-type, eukaryotic

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All nucleic 7

cDNA 3

Primer pair 4

Microarray probesets 1

Summaries

All 32

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 14
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trim55:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28518	Chr3:19698616-19698630 (+)	-15 bp
Tssr28519	Chr3:19698631-19698638 (+)	-3 bp
Tssr28520	Chr3:19698681-19698693 (+)	49 bp
Tssr28521	Chr3:19698732-19698737 (+)	97 bp
Tssr28522	Chr3:19698740-19698753 (+)	109 bp
Tssr28523	Chr3:19733197-19733206 (+)	34,564 bp
Tssr28524	Chr3:19741244-19741247 (+)	42,608 bp
Tssr28525	Chr3:19743975-19743987 (+)	45,343 bp
Tssr28526	Chr3:19744181-19744184 (+)	45,545 bp
Tssr28527	Chr3:19746096-19746108 (+)	47,464 bp
Tssr28528	Chr3:19746179-19746190 (+)	47,547 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24