Aox3 MGI Mouse Gene Detail - MGI:1918974

Symbol

Aox3
Name

aldehyde oxidase 3
Synonyms

1200011D03Rik, AOH1

Feature Type

protein coding gene
IDs

MGI:1918974
NCBI Gene: 71724
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:58152289-58239857 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 28.96 cM
Mapping Data

5 experiments

SNPs within 2kb

2843 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918974	protein coding gene	Chr1:58152289-58241380 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016046	protein coding gene	Chr1:57951945-58042399 (+)
A/J	MGP_AJ_G0016029	protein coding gene	Chr1:55936678-56025359 (+)
AKR/J	MGP_AKRJ_G0015985	protein coding gene	Chr1:57439320-57531664 (+)
BALB/cJ	MGP_BALBcJ_G0015984	protein coding gene	Chr1:55967208-56054684 (+)
C3H/HeJ	MGP_C3HHeJ_G0015816	protein coding gene	Chr1:57715836-57805342 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016437	protein coding gene	Chr1:60318949-60408371 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014159	protein coding gene	Chr1:51871909-51961211 (+)
CAST/EiJ	MGP_CASTEiJ_G0015398	protein coding gene	Chr1:56969055-57056192 (+)
CBA/J	MGP_CBAJ_G0015788	protein coding gene	Chr1:62071815-62162993 (+)
DBA/2J	MGP_DBA2J_G0015889	protein coding gene	Chr1:55340304-55427433 (+)
FVB/NJ	MGP_FVBNJ_G0015891	protein coding gene	Chr1:54675909-54762635 (+)
LP/J	MGP_LPJ_G0015961	protein coding gene	Chr1:58840650-58931931 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015911	protein coding gene	Chr1:65085013-65177108 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016484	protein coding gene	Chr1:57425401-57524790 (+)
PWK/PhJ	MGP_PWKPhJ_G0015184	protein coding gene	Chr1:54722110-54815635 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014965	protein coding gene	Chr1:57014752-57103023 (+)
WSB/EiJ	MGP_WSBEiJ_G0015461	protein coding gene	Chr1:57106195-57191560 (+)

Human Ortholog

AOX3P, aldehyde oxidase 3, pseudogene

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AOX3P, aldehyde oxidase 3, pseudogene
Synonyms

AOH1, AOX3
Links

HGNC:19049

NCBI Gene ID: 107126360
Chr Location

2q33.1; chr2:200678233-200738781 (+) GRCh38

MGI Vertebrate Homology

Aox3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AOX3P
Protein SuperFamily

Xanthine_DH
Gene Tree

Aox3

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Radiation induced

1
Genomic Mutations

2 involving Aox3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

71 strains or lines available

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

25
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

94
RefSeq

8
UniProt

7
CCDS

CCDS14969.1

Ensembl

ENSMUSG00000064294 (Evidence)
NCBI Gene

71724

			Length	Strain/Species	Flank
genomic	ENSMUSG00000064294	Ensembl Gene Model \| MGI Sequence Detail	87569	C57BL/6J	± kb
transcript	ENSMUST00000040999	Ensembl \| MGI Sequence Detail	4606	Not Applicable
polypeptide	ENSMUSP00000049391	Ensembl \| MGI Sequence Detail	1335	Not Applicable

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UniProt

7 Sequences
PDB

3ZYV
EC

1.17.3.-, 1.2.3.1
InterPro Domains

IPR002888 [2Fe-2S]-binding

IPR036884 [2Fe-2S]-binding domain superfamily

IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site

IPR036010 2Fe-2S ferredoxin-like superfamily

IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain

IPR014313 Aldehyde oxidase

IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead

IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily

IPR008274 Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain

IPR016208 Aldehyde oxidase/xanthine dehydrogenase-like

IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily

IPR046867 Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain

IPR012675 Beta-grasp domain superfamily

IPR005107 CO dehydrogenase flavoprotein, C-terminal

IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamily

IPR016166 FAD-binding domain, PCMH-type

IPR036318 FAD-binding, type PCMH-like superfamily

IPR016167 FAD-binding, type PCMH, subdomain 1

IPR016169 FAD-binding, type PCMH, subdomain 2

IPR002346 Molybdopterin dehydrogenase, FAD-binding
GlyGen

G3X982 1 site, 1 O-linked glycan (1 site)

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All nucleic 25

cDNA 25

Microarray probesets 3

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MGI:2138211

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:327415 Jing J, et al., Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803

TSS for Aox3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6758	Chr1:58152325-58152343 (+)	45 bp
Tssr6759	Chr1:58154510-58154553 (+)	2,243 bp
Tssr6760	Chr1:58154578-58154592 (+)	2,296 bp
Tssr6761	Chr1:58161387-58161410 (+)	9,110 bp
Tssr6762	Chr1:58222657-58222658 (+)	70,369 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24