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Alkal1 Gene Detail
Summary
  • Symbol
    Alkal1
  • Name
    ALK and LTK ligand 1
  • Synonyms
    Augbeta, Augmentor beta, EG620393, Fam150a
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645495
    NCBI Gene: 620393
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:6429555-6464955 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 1.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1298 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645495
 protein coding gene Chr1:6429442-6464955 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015819
 protein coding gene Chr1:3548602-3590065 (+)
A/J MGP_AJ_G0015801
 protein coding gene Chr1:3506925-3542609 (+)
AKR/J MGP_AKRJ_G0015760
 protein coding gene Chr1:3486577-3521602 (+)
BALB/cJ MGP_BALBcJ_G0015757
 protein coding gene Chr1:3390144-3432566 (+)
C3H/HeJ MGP_C3HHeJ_G0015591
 protein coding gene Chr1:3459513-3499114 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016209
 protein coding gene Chr1:3617958-3661240 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013931
 protein coding gene Chr1:3003689-3036839 (+)
CAST/EiJ MGP_CASTEiJ_G0015171
 protein coding gene Chr1:3641656-3679751 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0015663
 protein coding gene Chr1:3346577-3380591 (+)
FVB/NJ MGP_FVBNJ_G0015668
 protein coding gene Chr1:3290553-3326175 (+)
LP/J MGP_LPJ_G0015736
 protein coding gene Chr1:3621472-3656031 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015687
 protein coding gene Chr1:4074065-4111483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016256
 protein coding gene Chr1:3446185-3484131 (+)
PWK/PhJ MGP_PWKPhJ_G0014955
 protein coding gene Chr1:3236482-3268597 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014735
 protein coding gene Chr1:3626461-3660144 (+)
WSB/EiJ MGP_WSBEiJ_G0015235
 protein coding gene Chr1:3401052-3439957 (+)



Homology
more
  • Human Ortholog
    ALKAL1, ALK and LTK ligand 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKAL1, ALK and LTK ligand 1
  • Synonyms
    AUGA, AUGB, FAM150A, UNQ9433
  • Links
    NCBI Gene ID: 389658
    neXtProt AC: NX_Q6UXT8
    UniProt: Q6UXT8

  • Chr Location
    8q11.23; chr8:52534037-52565430 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    5 phenotype references
Homozygous deletion of this gene results in normal body weight curves with no apparent thinness phenotype on a standard chow diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 620393 NCBI Gene Model | MGI Sequence Detail 35401 C57BL/6J ±  kb
transcript NM_001195732 RefSeq | MGI Sequence Detail 858 C57BL/6  
polypeptide J3QPP8 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:5897449
References
more
  • Summaries
    All 21
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
  • Latest
    J:324631 Ahmed M, et al., A hypothalamic pathway for Augmentor alpha-controlled body weight regulation. Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2200476119
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory