About   Help   FAQ
Cdk5r1 Gene Detail
Summary
  • Symbol
    Cdk5r1
  • Name
    cyclin dependent kinase 5, regulatory subunit 1
  • Synonyms
    D11Bwg0379e, p25, p35
  • Feature Type
    protein coding gene
  • IDs
    MGI:101764
    NCBI Gene: 12569
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:80367849-80372010 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 47.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101764
 protein coding gene Chr11:80367849-80372010 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018814
 protein coding gene Chr11:81643948-81648109 (+)
A/J MGP_AJ_G0018781
 protein coding gene Chr11:78507046-78511207 (+)
AKR/J MGP_AKRJ_G0018751
 protein coding gene Chr11:80864159-80868320 (+)
BALB/cJ MGP_BALBcJ_G0018754
 protein coding gene Chr11:78905582-78909763 (+)
C3H/HeJ MGP_C3HHeJ_G0018568
 protein coding gene Chr11:80928237-80932361 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019206
 protein coding gene Chr11:84135544-84139705 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016840
 protein coding gene Chr11:75437392-75441592 (+)
CAST/EiJ MGP_CASTEiJ_G0018123
 protein coding gene Chr11:81404886-81409063 (+)
CBA/J MGP_CBAJ_G0018539
 protein coding gene Chr11:87828281-87832442 (+)
DBA/2J MGP_DBA2J_G0018647
 protein coding gene Chr11:78066893-78071055 (+)
FVB/NJ MGP_FVBNJ_G0018636
 protein coding gene Chr11:77635592-77639753 (+)
LP/J MGP_LPJ_G0018717
 protein coding gene Chr11:82169074-82173235 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018663
 protein coding gene Chr11:88086724-88101811 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019246
 protein coding gene Chr11:81130210-81134371 (+)
PWK/PhJ MGP_PWKPhJ_G0017893
 protein coding gene Chr11:78882215-78886398 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017684
 protein coding gene Chr11:80720360-80724523 (+)
WSB/EiJ MGP_WSBEiJ_G0018175
 protein coding gene Chr11:80958786-80962967 (+)



Homology
more
  • Human Ortholog
    CDK5R1, cyclin dependent kinase 5 regulatory subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK5R1, cyclin dependent kinase 5 regulatory subunit 1
  • Synonyms
    CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
  • Links
    NCBI Gene ID: 8851
    neXtProt AC: NX_Q15078
    UniProt: Q15078

  • Chr Location
    17q11.2; chr17:32486993-32491253 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cdk5r1 mouse models; 1 with human CDK5R1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 5 alleles in 7 genetic backgrounds
    24 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of the gene results in structural abnormalities of the brain such as a small corpus callosum and delaminated cerebral cortex. Mice show hyperactivity and decreased locomotion in response to stimulants.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    999
  • Tissues
    173
  • cDNA Data
    17
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12569 NCBI Gene Model | MGI Sequence Detail 4162 C57BL/6J ±  kb
    transcript NM_009871 RefSeq | MGI Sequence Detail 4187 ZRU/MplStud  
    polypeptide P61809 UniProt | EBI | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 3
      cDNA 18
      Primer pair 4
      Other 5

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-18570, MGD-MRK-34066, MGI:106373
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 40
      Diseases 1
      Gene Ontology 28
      Phenotypes 73
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:347592 Fei Q, et al., Timing dependent neuronal migration is regulated by Cdk5-mediated phosphorylation of JIP1. Front Cell Dev Biol. 2024;12:1371568
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory