Ryk MGI Mouse Gene Detail - MGI:101766 - receptor-like tyrosine kinase

Symbol

Ryk
Name

receptor-like tyrosine kinase
Synonyms

ERK-3, Vik

Feature Type

protein coding gene
IDs

MGI:101766
NCBI Gene: 20187
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:102712119-102785506 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 54.72 cM
Mapping Data

6 experiments

SNPs within 2kb

2112 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101766	protein coding gene	Chr9:102712116-102785506 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035191	protein coding gene	Chr9:104419455-104498339 (+)
A/J	MGP_AJ_G0035171	protein coding gene	Chr9:100669562-100743184 (+)
AKR/J	MGP_AKRJ_G0035103	protein coding gene	Chr9:103153878-103228846 (+)
BALB/cJ	MGP_BALBcJ_G0035164	protein coding gene	Chr9:100377654-100451577 (+)
C3H/HeJ	MGP_C3HHeJ_G0034874	protein coding gene	Chr9:103551892-103631770 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035684	protein coding gene	Chr9:107334785-107413062 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032583	protein coding gene	Chr9:98253404-98327426 (+)
CAST/EiJ	MGP_CASTEiJ_G0034186	protein coding gene	Chr9:103385456-103463777 (+)
CBA/J	MGP_CBAJ_G0034843	protein coding gene	Chr9:111085372-111166995 (+)
DBA/2J	MGP_DBA2J_G0035004	protein coding gene	Chr9:100164189-100237006 (+)
FVB/NJ	MGP_FVBNJ_G0034952	protein coding gene	Chr9:98960884-99032896 (+)
LP/J	MGP_LPJ_G0035080	protein coding gene	Chr9:104629927-104706877 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034991	protein coding gene	Chr9:112892142-112967974 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035706	protein coding gene	Chr9:103405981-103481239 (+)
PWK/PhJ	MGP_PWKPhJ_G0033893	protein coding gene	Chr9:100406231-100482243 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033728	protein coding gene	Chr9:103447749-103519744 (+)
WSB/EiJ	MGP_WSBEiJ_G0034306	protein coding gene	Chr9:103287430-103364854 (+)

Human Ortholog

RYK, receptor like tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RYK, receptor like tyrosine kinase
Synonyms

D3S3195, JTK5, JTK5A, RYK1
Links

HGNC:10481

NCBI Gene ID: 6259

neXtProt AC: NX_P34925

UniProt: P34925
Chr Location

3q22.2; chr3:134065303-134250859 (-) GRCh38

MGI Vertebrate Homology

Ryk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RYK
Protein SuperFamily

TyrPK_CSF1-R
Gene Tree

Ryk

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Phenotype Summary

35 phenotypes from 2 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have a distinctive craniofacial appearance, shortened limbs and postnatal mortality due to feeding and respiratory complications associated with a complete cleft of the secondary palate.

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All GO Annotations

59
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1059
Tissues

177
cDNA Data

124
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ryk

ZFIN ryk

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All Sequences

57
RefSeq

6
UniProt

4
CCDS

CCDS40747.1, CCDS57696.1

Ensembl

ENSMUSG00000032547 (Evidence)
NCBI Gene

20187

			Length	Strain/Species	Flank
genomic	20187	NCBI Gene Model \| MGI Sequence Detail	73388	C57BL/6J	± kb
transcript	NM_013649	RefSeq \| MGI Sequence Detail	3267	ZRU/MplStud
polypeptide	Q01887	UniProt \| EBI \| MGI Sequence Detail	594	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014376 tyrosine-protein kinase RYK

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR003306 WIF domain

IPR038677 WIF domain superfamily
GlyGen

Q01887 5 sites, 1 N-linked glycan (1 site)

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All nucleic 133

cDNA 125

Primer pair 2

Other 6

Microarray probesets 5

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MGD-MRK-18573, MGI:2143310

Summaries

All 88

Developmental Gene Expression 25

Gene Ontology 19

Phenotypes 30
Earliest

J:31015 Hanks SK, et al., The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 1988 Jul 1;241(4861):42-52
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ryk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86740	Chr9:102712063-102712146 (+)	-14 bp
Tssr86741	Chr9:102712160-102712171 (+)	47 bp
Tssr86742	Chr9:102712178-102712189 (+)	65 bp
Tssr86743	Chr9:102741711-102741722 (+)	29,598 bp
Tssr86744	Chr9:102777402-102777409 (+)	65,287 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24