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Tango2 Gene Detail
Summary
  • Symbol
    Tango2
  • Name
    transport and golgi organization 2
  • Synonyms
    D16H22S680E, T10
  • Feature Type
    protein coding gene
  • IDs
    MGI:101825
    NCBI Gene: 27883
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18118689-18165962 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.34 cM, cytoband B1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101825
 protein coding gene Chr16:18118689-18165967 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022608
 protein coding gene Chr16:15517066-15568100 (-)
A/J MGP_AJ_G0022569
 protein coding gene Chr16:14746134-14794610 (-)
AKR/J MGP_AKRJ_G0022546
 protein coding gene Chr16:15331042-15382192 (-)
BALB/cJ MGP_BALBcJ_G0022574
 protein coding gene Chr16:14895151-14942920 (-)
C3H/HeJ MGP_C3HHeJ_G0022341
 protein coding gene Chr16:15487103-15534082 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023023
 protein coding gene Chr16:15792303-15841449 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020543
 protein coding gene Chr16:14789275-14833280 (-)
CAST/EiJ MGP_CASTEiJ_G0021868
 protein coding gene Chr16:15380309-15430380 (-)
CBA/J MGP_CBAJ_G0022310
 protein coding gene Chr16:16487446-16544518 (-)
DBA/2J MGP_DBA2J_G0022442
 protein coding gene Chr16:14664410-14712661 (-)
FVB/NJ MGP_FVBNJ_G0022417
 protein coding gene Chr16:14699958-14765181 (-)
LP/J MGP_LPJ_G0022509
 protein coding gene Chr16:15294837-15341778 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022439
 protein coding gene Chr16:16125487-16179133 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023034
 protein coding gene Chr16:15262651-15316378 (-)
PWK/PhJ MGP_PWKPhJ_G0021610
 protein coding gene Chr16:14936259-14981737 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021438
 protein coding gene Chr16:15224343-15274260 (-)
WSB/EiJ MGP_WSBEiJ_G0021914
 protein coding gene Chr16:15258705-15310280 (-)



Homology
more
  • Human Ortholog
    TANGO2, transport and golgi organization 2 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TANGO2, transport and golgi organization 2 homolog
  • Synonyms
    C22orf25, MECRCN
  • Links
    NCBI Gene ID: 128989
    neXtProt AC: NX_Q6ICL3
    UniProt: Q6ICL3

  • Chr Location
    22q11.21; chr22:20017014-20067164 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TANGO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    139 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    62
  • cDNA Data
    84
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27883 NCBI Gene Model | MGI Sequence Detail 47274 C57BL/6J ±  kb
    transcript NM_001359110 RefSeq | MGI Sequence Detail 1748 ZRU/MplStud  
    polypeptide P54797 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000016002 transport and Golgi organization protein 2
      (term hierarchy)
    • InterPro Domains
      IPR008551 Transport and Golgi organisation protein 2
    • GlyGen
      P54797 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 111
      Genomic 25
      cDNA 84
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18644
    References
    more
    • Summaries
      All 171
      Developmental Gene Expression 7
      Diseases 6
      Gene Ontology 5
      Phenotypes 139
    • Earliest
      J:15242 Halford S, et al., Isolation of a gene expressed during early embryogenesis from the region of 22q11 commonly deleted in DiGeorge syndrome. Hum Mol Genet. 1993 Oct;2(10):1577-82
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory