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Tubg1 Gene Detail
Summary
  • Symbol
    Tubg1
  • Name
    tubulin, gamma 1
  • Synonyms
    1500010O08Rik, MGC:8041
  • Feature Type
    protein coding gene
  • IDs
    MGI:101834
    NCBI Gene: 103733
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101010764-101017245 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.24 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    263 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101834
 protein coding gene Chr11:101010725-101017249 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019182
 protein coding gene Chr11:103934357-103943739 (+)
A/J MGP_AJ_G0019150
 protein coding gene Chr11:99578331-99584144 (+)
AKR/J MGP_AKRJ_G0019119
 protein coding gene Chr11:102675248-102682637 (+)
BALB/cJ MGP_BALBcJ_G0019124
 protein coding gene Chr11:100071493-100078605 (+)
C3H/HeJ MGP_C3HHeJ_G0018933
 protein coding gene Chr11:102844320-102851561 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019573
 protein coding gene Chr11:107157539-107164868 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017199
 protein coding gene Chr11:96996680-97002881 (+)
CAST/EiJ MGP_CASTEiJ_G0018487
 protein coding gene Chr11:103834301-103840994 (+)
CBA/J MGP_CBAJ_G0018902
 protein coding gene Chr11:111616397-111626567 (+)
DBA/2J MGP_DBA2J_G0019014
 protein coding gene Chr11:99111981-99118375 (+)
FVB/NJ MGP_FVBNJ_G0019004
 protein coding gene Chr11:98655470-98661226 (+)
LP/J MGP_LPJ_G0019083
 protein coding gene Chr11:104481498-104488346 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019035
 protein coding gene Chr11:111179484-111185821 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019611
 protein coding gene Chr11:102993630-103002781 (+)
PWK/PhJ MGP_PWKPhJ_G0018250
 protein coding gene Chr11:100163335-100170103 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018042
 protein coding gene Chr11:102733388-102739263 (+)
WSB/EiJ MGP_WSBEiJ_G0018536
 protein coding gene Chr11:102996159-103002463 (+)



Homology
more
  • Human Ortholog
    TUBG1, tubulin gamma 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBG1, tubulin gamma 1
  • Synonyms
    CDCBM4, GCP-1, TUBG, TUBGCP1
  • Links
    NCBI Gene ID: 7283
    neXtProt AC: NX_P23258
    UniProt: P23258

  • Chr Location
    17q21.2; chr17:42609641-42615238 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tubg1 mouse models; 3 with human TUBG1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality and growth arrest at the blastocyst stage. Heterozygosity for the p.Y92C mutation affects cerebral cortex and hippocampus development and leads to increased locomotor activity, impaired fear conditioning behavior and increased sensitivity to chemically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    45
  • cDNA Data
    6
  • Literature Summary
    174
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035198 Ensembl Gene Model | MGI Sequence Detail 6482 C57BL/6J ±  kb
    transcript ENSMUST00000043680 Ensembl | MGI Sequence Detail 1802 Not Applicable  
    polypeptide ENSMUSP00000048036 Ensembl | MGI Sequence Detail 451 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18655, MGI:1923590, MGI:2144173, MGI:2144203
    References
    more
    • Summaries
      All 245
      Developmental Gene Expression 174
      Diseases 1
      Gene Ontology 20
      Phenotypes 16
    • Earliest
      J:12193 Gueth-Hallonet C, et al., gamma-Tubulin is present in acentriolar MTOCs during early mouse development. J Cell Sci. 1993 May;105(Pt 1):157-66
    • Latest
      J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory