Pla2g1b MGI Mouse Gene Detail - MGI:101842 - phospholipase A2, group IB, pancreas

Symbol

Pla2g1b
Name

phospholipase A2, group IB, pancreas
Synonyms

Pla2a, sPLA2IB

Feature Type

protein coding gene
IDs

MGI:101842
NCBI Gene: 18778
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr5:115604321-115612781 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 56.10 cM, cytoband F1-G1.1
Mapping Data

5 experiments

SNPs within 2kb

383 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101842	protein coding gene	Chr5:115604201-115612781 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029970	protein coding gene	Chr5:118351531-118362923 (+)
A/J	MGP_AJ_G0029934	protein coding gene	Chr5:113635208-113644108 (+)
AKR/J	MGP_AKRJ_G0029873	protein coding gene	Chr5:117280475-117289658 (+)
BALB/cJ	MGP_BALBcJ_G0029945	protein coding gene	Chr5:115030948-115040537 (+)
C3H/HeJ	MGP_C3HHeJ_G0029665	protein coding gene	Chr5:117791056-117800500 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030400	protein coding gene	Chr5:122905793-122915626 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027627	protein coding gene	Chr5:108410763-108419572 (+)
CAST/EiJ	MGP_CASTEiJ_G0029074	protein coding gene	Chr5:116723746-116732723 (+)
CBA/J	MGP_CBAJ_G0029633	protein coding gene	Chr5:127629191-127643475 (+)
DBA/2J	MGP_DBA2J_G0029783	protein coding gene	Chr5:113710460-113736599 (+)
FVB/NJ	MGP_FVBNJ_G0029739	protein coding gene	Chr5:112540859-112549204 (+)
LP/J	MGP_LPJ_G0029871	protein coding gene	Chr5:118910318-118920893 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029770	protein coding gene	Chr5:131934189-131945861 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030441	protein coding gene	Chr5:116753403-116762567 (+)
PWK/PhJ	MGP_PWKPhJ_G0028787	protein coding gene	Chr5:112369220-112379280 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028625	protein coding gene	Chr5:114302418-114310623 (+)
WSB/EiJ	MGP_WSBEiJ_G0029149	protein coding gene	Chr5:117344476-117352670 (+)

Human Ortholog

PLA2G1B, phospholipase A2 group IB

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLA2G1B, phospholipase A2 group IB
Synonyms

PLA2, PLA2A, PPLA2
Links

HGNC:9030

NCBI Gene ID: 5319

neXtProt AC: NX_P04054

UniProt: P04054
Chr Location

12q24.31; chr12:120322115-120327779 (-) GRCh38

MGI Vertebrate Homology

Pla2g1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLA2G1B
Gene Tree

Pla2g1b

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

7
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Pla2g1b
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display abnormalities in lipid absorption, increased insulin sensitivity and improved glucose tolerance.

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All GO Annotations

52
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

102
cDNA Data

49
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pla2g1b

ZFIN pla2g1b

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All Sequences

66
RefSeq

7
UniProt

4
CCDS

CCDS19592.1, CCDS89977.1

Ensembl

ENSMUSG00000029522 (Evidence)
NCBI Gene

18778

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029522	Ensembl Gene Model \| MGI Sequence Detail	8461	C57BL/6J	± kb
transcript	ENSMUST00000031495	Ensembl \| MGI Sequence Detail	557	Not Applicable
polypeptide	ENSMUSP00000031495	Ensembl \| MGI Sequence Detail	146	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012798 phospholipase A2

(term hierarchy)
EC

3.1.1.4
InterPro Domains

IPR001211 Phospholipase A2

IPR033112 Phospholipase A2, aspartic acid active site

IPR016090 Phospholipase A2 domain

IPR036444 Phospholipase A2 domain superfamily

IPR033113 Phospholipase A2, histidine active site

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All nucleic 52

Genomic 1

cDNA 49

Primer pair 1

Other 1

Microarray probesets 7

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MGD-MRK-13343, MGD-MRK-18663

Summaries

All 59

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11

TSS for Pla2g1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48268	Chr5:115603148-115603172 (+)	-1,161 bp
Tssr48269	Chr5:115604211-115604218 (+)	-106 bp
Tssr48270	Chr5:115604234-115604248 (+)	-80 bp
Tssr48271	Chr5:115604293-115604353 (+)	2 bp
Tssr48272	Chr5:115606504-115606517 (+)	2,190 bp
Tssr48273	Chr5:115606535-115606548 (+)	2,221 bp
Tssr48274	Chr5:115608840-115608852 (+)	4,525 bp
Tssr48275	Chr5:115608870-115608887 (+)	4,558 bp
Tssr48276	Chr5:115608895-115608900 (+)	4,577 bp
Tssr48277	Chr5:115608912-115608924 (+)	4,597 bp
Tssr48278	Chr5:115608929-115608939 (+)	4,613 bp
Tssr48279	Chr5:115608947-115608976 (+)	4,641 bp
Tssr48280	Chr5:115609750-115609752 (+)	5,430 bp
Tssr48281	Chr5:115610040-115610062 (+)	5,730 bp
Tssr48282	Chr5:115610067-115610074 (+)	5,750 bp
Tssr48283	Chr5:115610081-115610139 (+)	5,789 bp
Tssr48284	Chr5:115612563-115612574 (+)	8,248 bp
Tssr48285	Chr5:115612577-115612634 (+)	8,285 bp
Tssr48286	Chr5:115612637-115612640 (+)	8,318 bp
Tssr48287	Chr5:115612671-115612697 (+)	8,363 bp
Tssr48288	Chr5:115612707-115612721 (+)	8,393 bp
Tssr48289	Chr5:115612732-115612741 (+)	8,416 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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