Rack1 MGI Mouse Gene Detail - MGI:101849 - receptor for activated C kinase 1

Symbol

Rack1
Name

receptor for activated C kinase 1
Synonyms

GB-like, Gnb2l1, Gnb2-rs1, p205

Feature Type

protein coding gene
IDs

MGI:101849
NCBI Gene: 14694
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:48691187-48697068 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 28.77 cM
Mapping Data

4 experiments

SNPs within 2kb

58 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101849	protein coding gene	Chr11:48691159-48697261 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018204	protein coding gene	Chr11:47828367-47834468 (+)
A/J	MGP_AJ_G0018175	protein coding gene	Chr11:45924293-45930355 (+)
AKR/J	MGP_AKRJ_G0018141	protein coding gene	Chr11:47347327-47353403 (+)
BALB/cJ	MGP_BALBcJ_G0018144	protein coding gene	Chr11:46138084-46144170 (+)
C3H/HeJ	MGP_C3HHeJ_G0017958	protein coding gene	Chr11:47354368-47363700 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018598	protein coding gene	Chr11:49262791-49270192 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016253	protein coding gene	Chr11:43789850-43795372 (+)
CAST/EiJ	MGP_CASTEiJ_G0017521	protein coding gene	Chr11:47518414-47526518 (+)
CBA/J	MGP_CBAJ_G0017930	protein coding gene	Chr11:51521900-51530956 (+)
DBA/2J	MGP_DBA2J_G0018040	protein coding gene	Chr11:45778652-45784768 (+)
FVB/NJ	MGP_FVBNJ_G0018034	protein coding gene	Chr11:45372404-45378488 (+)
LP/J	MGP_LPJ_G0018112	protein coding gene	Chr11:48071472-48077574 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018058	protein coding gene	Chr11:52982545-52989712 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018637	protein coding gene	Chr11:47511899-47519457 (+)
PWK/PhJ	MGP_PWKPhJ_G0017301	protein coding gene	Chr11:46172448-46178808 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017094	protein coding gene	Chr11:47245746-47252850 (+)
WSB/EiJ	MGP_WSBEiJ_G0017571	protein coding gene	Chr11:47145108-47151326 (+)

Human Ortholog

RACK1, receptor for activated C kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RACK1, receptor for activated C kinase 1
Synonyms

GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21
Links

HGNC:4399

NCBI Gene ID: 10399

neXtProt AC: NX_P63244

UniProt: P63244
Chr Location

5q35.3; chr5:181236897-181248096 (-) GRCh38

MGI Vertebrate Homology

Rack1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RACK1
Gene Tree

Rack1

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

83
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

75
Targeted

6
Genomic Mutations

1 involving Rack1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a hypomorphic allele lack early egg cylinders and die at gastrulation. Heterozygotes show a transient growth deficit, a white belly spot and hypopigmented tail and paws, while embryonic fibroblasts show a reduction in PMA- and insulin-stimulated translation.

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All GO Annotations

129
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

76
cDNA Data

1474
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rack1

ZFIN rack1

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All Sequences

60
RefSeq

2
UniProt

1
CCDS

CCDS24585.1

Ensembl

ENSMUSG00000020372 (Evidence)
NCBI Gene

14694

			Length	Strain/Species	Flank
genomic	14694	NCBI Gene Model \| MGI Sequence Detail	5882	C57BL/6J	± kb
transcript	NM_008143	RefSeq \| MGI Sequence Detail	1254	C57BL/6
polypeptide	P68040	UniProt \| EBI \| MGI Sequence Detail	317	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008098 small ribosomal subunit protein RACK1

(term hierarchy)
PDB

7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR045223 Small ribosomal subunit protein RACK1-like

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

P68040 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 1482

cDNA 1477

Primer pair 4

Other 1

Microarray probesets 4

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MGD-MRK-18672

Summaries

All 95

Developmental Gene Expression 16

Gene Ontology 18

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:337577 Oudart M, et al., The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity. Cell Rep. 2023 May 30;42(5):112456

TSS for Rack1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101138	Chr11:48690868-48690898 (+)	-304 bp
Tssr101139	Chr11:48691184-48691196 (+)	3 bp
Tssr101140	Chr11:48691218-48691220 (+)	32 bp
Tssr101145	Chr11:48694249-48694276 (+)	3,076 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24