Aldoc MGI Mouse Gene Detail - MGI:101863 - aldolase C, fructose-bisphosphate

Symbol

Aldoc
Name

aldolase C, fructose-bisphosphate
Synonyms

Aldo3, Aldolase C, Scrg2, zebrin II

Feature Type

protein coding gene
IDs

MGI:101863
NCBI Gene: 11676
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr11:78213899-78218607 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

2 experiments

SNPs within 2kb

172 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101863	protein coding gene	Chr11:78213794-78218607 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018775	protein coding gene	Chr11:79318255-79324855 (+)
A/J	MGP_AJ_G0018741	protein coding gene	Chr11:76286229-76291042 (+)
AKR/J	MGP_AKRJ_G0018711	protein coding gene	Chr11:78591671-78596484 (+)
BALB/cJ	MGP_BALBcJ_G0018715	protein coding gene	Chr11:76694917-76699726 (+)
C3H/HeJ	MGP_C3HHeJ_G0018528	protein coding gene	Chr11:78631573-78636385 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019166	protein coding gene	Chr11:81791797-81796606 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016801	protein coding gene	Chr11:73262136-73266921 (+)
CAST/EiJ	MGP_CASTEiJ_G0018082	protein coding gene	Chr11:79081069-79085865 (+)
CBA/J	MGP_CBAJ_G0018498	protein coding gene	Chr11:85371918-85376727 (+)
DBA/2J	MGP_DBA2J_G0018607	protein coding gene	Chr11:75864392-75869204 (+)
FVB/NJ	MGP_FVBNJ_G0018597	protein coding gene	Chr11:75453159-75457968 (+)
LP/J	MGP_LPJ_G0018678	protein coding gene	Chr11:79853358-79858167 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018623	protein coding gene	Chr11:85776895-85782721 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019206	protein coding gene	Chr11:78839356-78844171 (+)
PWK/PhJ	MGP_PWKPhJ_G0017853	protein coding gene	Chr11:76652820-76657644 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017644	protein coding gene	Chr11:78450501-78455317 (+)
WSB/EiJ	MGP_WSBEiJ_G0018135	protein coding gene	Chr11:78659900-78664709 (+)

Human Ortholog

ALDOC, aldolase, fructose-bisphosphate C

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALDOC, aldolase, fructose-bisphosphate C
Synonyms

ALDC
Links

HGNC:418

NCBI Gene ID: 230

neXtProt AC: NX_P09972

UniProt: P09972
Chr Location

17q11.2; chr17:28573115-28576948 (-) GRCh38

MGI Vertebrate Homology

Aldoc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ALDOC
Gene Tree

Aldoc

Diseases

1 with human ALDOC associations

				Human Disease	Mouse Models
				autoimmune disease of the nervous system IDs autoimmune disease of the nervous system DOID:438 MESH:D020274 NCI:C99383 UMLS_CUI:C0751871

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 4 genetic backgrounds
7 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

7
Genomic Mutations

2 involving Aldoc
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show decreased plasma levels of total cholesterol and HDL cholesterol in both sexes and decreased plasma triglyceride levels in females.

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All GO Annotations

21
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1053
Tissues

186
cDNA Data

16
Literature Summary

43

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aldoc

ZFIN aldoca, aldocb

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All Sequences

43
RefSeq

4
UniProt

1
CCDS

CCDS25099.1

Ensembl

ENSMUSG00000017390 (Evidence)
NCBI Gene

11676

			Length	Strain/Species	Flank
genomic	11676	NCBI Gene Model \| MGI Sequence Detail	4709	C57BL/6J	± kb
transcript	NM_009657	RefSeq \| MGI Sequence Detail	2723	ZRU/MplStud
polypeptide	P05063	UniProt \| EBI \| MGI Sequence Detail	363	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003936 fructose-bisphosphate aldolase C

(term hierarchy)
EC

4.1.2.13
InterPro Domains

IPR013785 Aldolase-type TIM barrel

IPR000741 Fructose-bisphosphate aldolase, class-I

IPR029768 Fructose-bisphosphate aldolase class-I active site
GlyGen

P05063 1 site, 1 O-linked glycan (1 site)

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All nucleic 22

Genomic 1

cDNA 16

Primer pair 4

Other 1

Microarray probesets 4

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MGD-MRK-18688, MGI:1328309, MGI:2144291, MGI:2144424

Summaries

All 117

Developmental Gene Expression 43

Gene Ontology 10

Phenotypes 33
Earliest

J:320599 Sato S, et al., Aldolase C in cultured mouse glioblastoma cells. Cancer Res. 1972 Jun;32(6):1290-2
Latest

J:352089 Grammer C, et al., Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258

TSS for Aldoc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103267	Chr11:78213791-78213822 (+)	-92 bp
Tssr103268	Chr11:78213894-78213906 (+)	1 bp
Tssr103269	Chr11:78213913-78213938 (+)	27 bp
Tssr103270	Chr11:78213946-78213971 (+)	60 bp
Tssr103271	Chr11:78213977-78213992 (+)	86 bp
Tssr103272	Chr11:78215051-78215062 (+)	1,158 bp
Tssr103273	Chr11:78215079-78215098 (+)	1,190 bp
Tssr103274	Chr11:78215113-78215127 (+)	1,221 bp
Tssr103275	Chr11:78215129-78215221 (+)	1,276 bp
Tssr103276	Chr11:78215230-78215241 (+)	1,337 bp
Tssr103277	Chr11:78215292-78215305 (+)	1,400 bp
Tssr103278	Chr11:78215462-78215474 (+)	1,569 bp
Tssr103279	Chr11:78215499-78215515 (+)	1,608 bp
Tssr103280	Chr11:78215539-78215588 (+)	1,665 bp
Tssr103281	Chr11:78215717-78215756 (+)	1,838 bp
Tssr103282	Chr11:78216759-78216769 (+)	2,865 bp
Tssr103283	Chr11:78217130-78217158 (+)	3,245 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24