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Ppard Gene Detail
Summary
  • Symbol
    Ppard
  • Name
    peroxisome proliferator activator receptor delta
  • Synonyms
    Nr1c2, NUC1, Peroxisome proliferator-activated receptor beta, Pparb, Pparb/d, PPAR-delta, PPARdelta/beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:101884
    NCBI Gene: 19015
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:28451715-28520446 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.64 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    363 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101884
 protein coding gene Chr17:28451674-28520448 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023436
 protein coding gene Chr17:27605542-27687098 (+)
A/J MGP_AJ_G0023394
 protein coding gene Chr17:26715471-26783132 (+)
AKR/J MGP_AKRJ_G0023359
 protein coding gene Chr17:26901258-26979253 (+)
BALB/cJ MGP_BALBcJ_G0023399
 protein coding gene Chr17:26977400-27049896 (+)
C3H/HeJ MGP_C3HHeJ_G0023160
 protein coding gene Chr17:27275543-27360382 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023841
 protein coding gene Chr17:28726745-28806207 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021316
 protein coding gene Chr17:24086231-24155277 (+)
CAST/EiJ MGP_CASTEiJ_G0022661
 protein coding gene Chr17:27260548-27336779 (+)
CBA/J MGP_CBAJ_G0023134
 protein coding gene Chr17:29744152-29826458 (+)
DBA/2J MGP_DBA2J_G0023265
 protein coding gene Chr17:26267274-26336633 (+)
FVB/NJ MGP_FVBNJ_G0023235
 protein coding gene Chr17:26067973-26142250 (+)
LP/J MGP_LPJ_G0023343
 protein coding gene Chr17:27861892-27939265 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023253
 protein coding gene Chr17:29184097-29261713 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023883
 protein coding gene Chr17:27319460-27396403 (+)
PWK/PhJ MGP_PWKPhJ_G0022411
 protein coding gene Chr17:25071575-25143967 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022229
 protein coding gene Chr17:25328895-25404464 (+)
WSB/EiJ MGP_WSBEiJ_G0022723
 protein coding gene Chr17:27315425-27396056 (+)



Homology
more
  • Human Ortholog
    PPARD, peroxisome proliferator activated receptor delta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPARD, peroxisome proliferator activated receptor delta
  • Synonyms
    FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB
  • Links
    NCBI Gene ID: 5467
    neXtProt AC: NX_Q03181
    UniProt: Q03181

  • Chr Location
    6p21.31; chr6:35342558-35428191 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ppard mouse models; 1 with human PPARD associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    106 phenotypes from 12 alleles in 11 genetic backgrounds
    9 phenotypes from multigenic genotypes
    2 images
    146 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a number of different targeted mutations show variable prenatal lethality and a range of phenotypes such as placental, brain, skin, hair follicle, adipose and lipid homeostasis abnormalities, growth retardation, reduced fertility, andincreased incidence of tumors/induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    146
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1183
  • Tissues
    272
  • cDNA Data
    46
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19015 NCBI Gene Model | MGI Sequence Detail 68732 C57BL/6J ±  kb
    transcript NM_011145 RefSeq | MGI Sequence Detail 3231 ZRU/MplStud  
    polypeptide P35396 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013057 peroxisome proliferator-activated receptor delta
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR050234 Nuclear hormone receptor family NR1 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003074 Peroxisome proliferator-activated receptor
      IPR003075 Peroxisome proliferator-activated receptor, beta
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 46
      Primer pair 8
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18710
    References
    more
    • Summaries
      All 289
      Developmental Gene Expression 35
      Diseases 2
      Gene Ontology 27
      Phenotypes 146
    • Earliest
      J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
    • Latest
      J:352196 Rangasamy SB, et al., Treadmill workout activates PPARalpha in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease. Brain Behav Immun. 2023 Jan 19;109:204-218
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory