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Klra4 Gene Detail
Summary
  • Symbol
    Klra4
  • Name
    killer cell lectin-like receptor, subfamily A, member 4
  • Synonyms
    Chok, Ly49d, ly49r129
  • Feature Type
    protein coding gene
  • IDs
    MGI:101904
    NCBI Gene: 16635
  • Member of
    Klra cluster
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:130020694-130044234 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    699 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101904
 protein coding gene Chr6:130020693-130044242 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0031334
 protein coding gene Chr6:128529210-128547553 (-)
AKR/J MGP_AKRJ_G0031262
 protein coding gene Chr6:132025953-132048480 (-)
BALB/cJ MGP_BALBcJ_G0031341
 protein coding gene Chr6:128426866-128444541 (-)
C3H/HeJ MGP_C3HHeJ_G0031064
 protein coding gene Chr6:132246520-132269155 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031802
 protein coding gene Chr6:137384720-137412496 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031183
 protein coding gene Chr6:127465253-127486056 (-)
FVB/NJ MGP_FVBNJ_G0031138
 protein coding gene Chr6:126829863-126853467 (-)
LP/J MGP_LPJ_G0031267
 protein coding gene Chr6:133901692-134212092 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031171
 protein coding gene Chr6:146474986-146491727 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0030161
 protein coding gene Chr6:125718982-125925191 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0017886
 protein coding gene Chr11:68882457-68904726 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079852 Ensembl Gene Model | MGI Sequence Detail 23541 C57BL/6J ±  kb
transcript ENSMUST00000119096 Ensembl | MGI Sequence Detail 1245 Not Applicable  
polypeptide ENSMUSP00000114004 Ensembl | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009619 killer cell lectin-like receptor 4
    (term hierarchy)
  • InterPro Domains
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR013600 Ly49-like, N-terminal
    IPR052013 Mouse Killer cell lectin-like receptors
    IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
  • GlyGen
    Q60651 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 23
    Genomic 17
    cDNA 5
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-18731
References
more
  • Summaries
    All 41
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:10723 Yokoyama WM, et al., Chromosomal location of the Ly-49 (A1, YE1/48) multigene family. Genetic association with the NK 1.1 antigen. J Immunol. 1990 Oct 1;145(7):2353-8
  • Latest
    J:254664 Nabekura T, et al., Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection. Immunity. 2016 Jul 19;45(1):74-82
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory