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Dad1 Gene Detail
Summary
  • Symbol
    Dad1
  • Name
    defender against cell death 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101912
    NCBI Gene: 13135
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54472942-54491386 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    574 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101912
 protein coding gene Chr14:54472936-54491561 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021303
 protein coding gene Chr14:48165270-48188750 (-)
A/J MGP_AJ_G0021262
 protein coding gene Chr14:47256349-47275128 (-)
AKR/J MGP_AKRJ_G0021238
 protein coding gene Chr14:48967427-48986162 (-)
BALB/cJ MGP_BALBcJ_G0021266
 protein coding gene Chr14:47227457-47246539 (-)
C3H/HeJ MGP_C3HHeJ_G0021046
 protein coding gene Chr14:48646260-48665481 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021705
 protein coding gene Chr14:50633940-50652468 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019249
 protein coding gene Chr14:45668599-45688619 (-)
CAST/EiJ MGP_CASTEiJ_G0020565
 protein coding gene Chr14:44881202-44901040 (-)
CBA/J MGP_CBAJ_G0021013
 protein coding gene Chr14:52123384-52145063 (-)
DBA/2J MGP_DBA2J_G0021134
 protein coding gene Chr14:47001401-47021087 (-)
FVB/NJ MGP_FVBNJ_G0021116
 protein coding gene Chr14:46454749-46473384 (-)
LP/J MGP_LPJ_G0021208
 protein coding gene Chr14:49195070-49215730 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021140
 protein coding gene Chr14:51566109-51584767 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021731
 protein coding gene Chr14:48146453-48165500 (-)
PWK/PhJ MGP_PWKPhJ_G0020311
 protein coding gene Chr14:43524606-43543680 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020139
 protein coding gene Chr14:44126830-44149371 (-)
WSB/EiJ MGP_WSBEiJ_G0020618
 protein coding gene Chr14:48440939-48459662 (-)



Homology
more
  • Human Ortholog
    DAD1, defender against cell death 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAD1, defender against cell death 1
  • Synonyms
    OST2
  • Links
    NCBI Gene ID: 1603
    neXtProt AC: NX_P61803
    UniProt: P61803

  • Chr Location
    14q11.2; chr14:22564907-22589224 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display fully penetrant embryonic lethality before somite formation and impaired growth. Heterozygous null mice display incompletely penetrant embryonic lethality, impaired embryonic growth, syndactyly, and mild thymic hypoplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1023
  • Tissues
    175
  • cDNA Data
    168
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13135 NCBI Gene Model | MGI Sequence Detail 18445 C57BL/6J ±  kb
    transcript NM_010015 RefSeq | MGI Sequence Detail 3506 ZRU/MplStud  
    polypeptide P61804 UniProt | EBI | MGI Sequence Detail 113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 172
      cDNA 169
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18741, MGI:2145618
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:22684 Nakashima T, et al., Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol Cell Biol. 1993 Oct;13(10):6367-74
    • Latest
      J:319945 Ramirez AS, et al., Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Science. 2019 Dec 13;366(6471):1372-1375
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory