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Calb2 Gene Detail
Summary
  • Symbol
    Calb2
  • Name
    calbindin 2
  • Synonyms
    calretinin, CR
  • Feature Type
    protein coding gene
  • IDs
    MGI:101914
    NCBI Gene: 12308
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110869158-110894844 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    804 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101914
 protein coding gene Chr8:110864134-110894844 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034122
 protein coding gene Chr8:112783024-112813733 (-)
A/J MGP_AJ_G0034101
 protein coding gene Chr8:108212446-108240221 (-)
AKR/J MGP_AKRJ_G0034028
 protein coding gene Chr8:111397564-111429677 (-)
BALB/cJ MGP_BALBcJ_G0034095
 protein coding gene Chr8:108410820-108439219 (-)
C3H/HeJ MGP_C3HHeJ_G0033806
 protein coding gene Chr8:112096923-112124928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034615
 protein coding gene Chr8:116765498-116793167 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031557
 protein coding gene Chr8:101234229-101260607 (-)
CAST/EiJ MGP_CASTEiJ_G0033133
 protein coding gene Chr8:111705398-111733961 (-)
CBA/J MGP_CBAJ_G0033780
 protein coding gene Chr8:120687968-120723772 (-)
DBA/2J MGP_DBA2J_G0033935
 protein coding gene Chr8:107530232-107556710 (-)
FVB/NJ MGP_FVBNJ_G0033879
 protein coding gene Chr8:106477952-106506876 (-)
LP/J MGP_LPJ_G0034025
 protein coding gene Chr8:112965853-112995455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033925
 protein coding gene Chr8:123684939-123715280 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034634
 protein coding gene Chr8:111348234-111375453 (-)
PWK/PhJ MGP_PWKPhJ_G0032836
 protein coding gene Chr8:107098961-107125756 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032675
 protein coding gene Chr8:110032927-110062664 (-)
WSB/EiJ MGP_WSBEiJ_G0033249
 protein coding gene Chr8:112032346-112062077 (-)



Homology
more
  • Human Ortholog
    CALB2, calbindin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CALB2, calbindin 2
  • Synonyms
    CAB29, CAL2, CR
  • Links
    NCBI Gene ID: 794
    neXtProt AC: NX_P22676
    UniProt: P22676

  • Chr Location
    16q22.2; chr16:71358713-71390436 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants showed normal growth, normal brain histology, and generally normal behavior. Impaired motor coordination was observed in wheel running in young and old mutant mice, and progressive impairment was seen on the runway and horizontal stationary rod tests in older mice. Abnormalities are observed in Purkinje cell firing, altering both simple and complex spikes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1624
  • Tissues
    371
  • cDNA Data
    41
  • Literature Summary
    648
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12308 NCBI Gene Model | MGI Sequence Detail 25687 C57BL/6J ±  kb
transcript NM_007586 RefSeq | MGI Sequence Detail 1449 C57BL/6  
polypeptide Q08331 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    Genomic 2
    cDNA 42
    Primer pair 8
    Other 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18743
References
more
  • Summaries
    All 790
    Developmental Gene Expression 648
    Gene Ontology 7
    Phenotypes 104
  • Earliest
    J:17458 Ninomiya T, et al., Mouse fetal trisomy 13 and hypotrophy of the spinal cord: effect on calbindin-D28k and calretinin expressed by neurons of the spinal cord and dorsal root ganglia. Neuroscience. 1993 Dec;57(4):1109-20
  • Latest
    J:355616 Naffaa MM, et al., A cholinergic signaling pathway underlying cortical circuit activation of quiescent neural stem cells in the lateral ventricle. Sci Signal. 2024 Sep 24;17(855):eadk8810
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory