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Akr1b7 Gene Detail
Summary
  • Symbol
    Akr1b7
  • Name
    aldo-keto reductase family 1, member B7
  • Synonyms
    Avdp, MVDP
  • Feature Type
    protein coding gene
  • IDs
    MGI:101918
    NCBI Gene: 11997
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34389297-34400072 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 14.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    564 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101918
 protein coding gene Chr6:34389269-34400077 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030559
 protein coding gene Chr6:32493798-32504611 (+)
A/J MGP_AJ_G0030532
 protein coding gene Chr6:31108352-31119162 (+)
AKR/J MGP_AKRJ_G0030459
 protein coding gene Chr6:32162444-32173267 (+)
BALB/cJ MGP_BALBcJ_G0030542
 protein coding gene Chr6:31290474-31303525 (+)
C3H/HeJ MGP_C3HHeJ_G0030255
 protein coding gene Chr6:32112778-32123600 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030996
 protein coding gene Chr6:33315008-33325910 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028208
 protein coding gene Chr6:29199439-29210312 (+)
CAST/EiJ MGP_CASTEiJ_G0029657
 protein coding gene Chr6:31936194-31946947 (+)
CBA/J MGP_CBAJ_G0030233
 protein coding gene Chr6:34589758-34600574 (+)
DBA/2J MGP_DBA2J_G0030377
 protein coding gene Chr6:30985355-30996165 (+)
FVB/NJ MGP_FVBNJ_G0030331
 protein coding gene Chr6:30777503-30788247 (+)
LP/J MGP_LPJ_G0030464
 protein coding gene Chr6:32624951-32635774 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030367
 protein coding gene Chr6:36935567-36947302 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031026
 protein coding gene Chr6:32035738-32047796 (+)
PWK/PhJ MGP_PWKPhJ_G0029371
 protein coding gene Chr6:30595721-30606368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029207
 protein coding gene Chr6:31696158-31706895 (+)
WSB/EiJ MGP_WSBEiJ_G0029733
 protein coding gene Chr6:31955082-31968613 (+)



Homology
more
  • Human Ortholog
    AKR1B10, aldo-keto reductase family 1 member B10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1B10, aldo-keto reductase family 1 member B10
  • Synonyms
    AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
  • Links
    NCBI Gene ID: 57016
    neXtProt AC: NX_O60218
    UniProt: O60218

  • Chr Location
    7q33; chr7:134527567-134541412 (+)  GRCh38
  • Human Ortholog
    AKR1B15, aldo-keto reductase family 1 member B15
  • Synonyms
    AKR1B10L, AKR1B10L, AK1R1B7, AKR1R1B7
  • Links
    NCBI Gene ID: 441282
    neXtProt AC: NX_C9JRZ8
    UniProt: C9JRZ8

  • Chr Location
    7q33; chr7:134549110-134579875 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit disrupted progesterone levels during estrous. Mice homozygous for a different knock-out allele exhibit increased basal adiposity and susceptibility to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    124
  • cDNA Data
    18
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11997 NCBI Gene Model | MGI Sequence Detail 10776 C57BL/6J ±  kb
    transcript NM_009731 RefSeq | MGI Sequence Detail 1248 Not Specified  
    polypeptide P21300 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 11
      cDNA 18
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18747
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 20
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:10833 Pailhoux EA, et al., Androgen-dependent protein from mouse vas deferens. cDNA cloning and protein homology with the aldo-keto reductase superfamily. J Biol Chem. 1990 Nov 15;265(32):19932-6
    • Latest
      J:354194 Oikonomakos I, et al., In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory