Pkib MGI Mouse Gene Detail - MGI:101937 - protein kinase inhibitor beta, cAMP dependent, testis specific

Symbol

Pkib
Name

protein kinase inhibitor beta, cAMP dependent, testis specific
Synonyms

PKIbeta, Prkacn2

Feature Type

protein coding gene
IDs

MGI:101937
NCBI Gene: 18768
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr10:57508077-57617208 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 29.22 cM
Mapping Data

6 experiments

SNPs within 2kb

2855 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101937	protein coding gene	Chr10:57508077-57617208 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017240	protein coding gene	Chr10:57007611-57123467 (+)
A/J	MGP_AJ_G0017216	protein coding gene	Chr10:55340756-55456886 (+)
AKR/J	MGP_AKRJ_G0017176	protein coding gene	Chr10:56503813-56615001 (+)
BALB/cJ	MGP_BALBcJ_G0017178	protein coding gene	Chr10:55456315-55566423 (+)
C3H/HeJ	MGP_C3HHeJ_G0017000	protein coding gene	Chr10:56729759-56841549 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017636	protein coding gene	Chr10:58786178-58901700 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015329	protein coding gene	Chr10:52201077-52294788 (+)
CAST/EiJ	MGP_CASTEiJ_G0016573	protein coding gene	Chr10:56674924-56789002 (+)
CBA/J	MGP_CBAJ_G0016972	protein coding gene	Chr10:61246915-61373305 (+)
DBA/2J	MGP_DBA2J_G0017077	protein coding gene	Chr10:54688498-54796492 (+)
FVB/NJ	MGP_FVBNJ_G0017072	protein coding gene	Chr10:53931186-54040462 (+)
LP/J	MGP_LPJ_G0017152	protein coding gene	Chr10:57095157-57219197 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017101	protein coding gene	Chr10:63461725-63581888 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017673	protein coding gene	Chr10:56316126-56429648 (+)
PWK/PhJ	MGP_PWKPhJ_G0016354	protein coding gene	Chr10:54476610-54583589 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016140	protein coding gene	Chr10:55992305-56091714 (+)
WSB/EiJ	MGP_WSBEiJ_G0016638	protein coding gene	Chr10:56523368-56634785 (+)

Human Ortholog

PKIB, cAMP-dependent protein kinase inhibitor beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PKIB, cAMP-dependent protein kinase inhibitor beta
Synonyms

PRKACN2
Links

HGNC:9018

NCBI Gene ID: 5570

neXtProt AC: NX_Q9C010

UniProt: Q9C010
Chr Location

6q22.31; chr6:122471917-122726373 (+) GRCh38

MGI Vertebrate Homology

Pkib stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PKIB
Protein SuperFamily

PKI
Gene Tree

Pkib

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
12 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Pkib
Incidental Mutations

CvDC
Find Mice (IMSR)

10 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a targeted null mutation exhibit reduced protein kinase inhibitor activity in the testis but are phenotypically normal and fertile.

less

All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

46
cDNA Data

30
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pkib

less

All Sequences

82
RefSeq

20
UniProt

8
CCDS

CCDS23854.1, CCDS23855.1

Ensembl

ENSMUSG00000019876 (Evidence)
NCBI Gene

18768

			Length	Strain/Species	Flank
genomic	18768	NCBI Gene Model \| MGI Sequence Detail	109132	C57BL/6J	± kb
transcript	NM_001039050	RefSeq \| MGI Sequence Detail	5581	NOD
polypeptide	Q04758	UniProt \| EBI \| MGI Sequence Detail	92	Not Applicable

less

UniProt

8 Sequences
Protein Ontology

PR:000012780 cAMP-dependent protein kinase inhibitor beta

(term hierarchy)
InterPro Domains

IPR004171 cAMP-dependent protein kinase inhibitor
GlyGen

Q04758 1 site, 1 O-linked glycan (1 site)

less

All nucleic 34

cDNA 30

Primer pair 3

Other 1

Microarray probesets 5

less

MGD-MRK-18770, MGD-MRK-37287, MGI:108248

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:315131 Koldaeva A, et al., Generation and Characterization of a Cell Type-Specific, Inducible Cre-Driver Line to Study Olfactory Processing. J Neurosci. 2021 Jul 28;41(30):6449-6467

TSS for Pkib:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93388	Chr10:57508142-57508156 (+)	72 bp
Tssr93389	Chr10:57508158-57508197 (+)	101 bp
Tssr93390	Chr10:57508204-57508216 (+)	133 bp
Tssr93391	Chr10:57521934-57521953 (+)	13,867 bp
Tssr93392	Chr10:57521957-57521982 (+)	13,893 bp
Tssr93393	Chr10:57521998-57522008 (+)	13,926 bp
Tssr93394	Chr10:57527050-57527056 (+)	18,976 bp
Tssr93395	Chr10:57527058-57527067 (+)	18,986 bp
Tssr93396	Chr10:57527073-57527081 (+)	19,000 bp
Tssr93397	Chr10:57527086-57527106 (+)	19,019 bp
Tssr93398	Chr10:57604036-57604064 (+)	95,973 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24