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Calcr Gene Detail
Summary
  • Symbol
    Calcr
  • Name
    calcitonin receptor
  • Synonyms
    Clr
  • Feature Type
    protein coding gene
  • IDs
    MGI:101950
    NCBI Gene: 12311
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:3685680-3764714 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 1.81 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1661 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101950
 protein coding gene Chr6:3685678-3764714 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030422
 protein coding gene Chr6:420697-501159 (-)
A/J MGP_AJ_G0030395
 protein coding gene Chr6:404202-484448 (-)
AKR/J MGP_AKRJ_G0030322
 protein coding gene Chr6:448913-528018 (-)
BALB/cJ MGP_BALBcJ_G0030404
 protein coding gene Chr6:401570-477691 (-)
C3H/HeJ MGP_C3HHeJ_G0030118
 protein coding gene Chr6:408009-493347 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030859
 protein coding gene Chr6:429031-507974 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028070
 protein coding gene Chr6:228665-304934 (-)
CAST/EiJ MGP_CASTEiJ_G0029519
 protein coding gene Chr6:403404-482331 (-)
CBA/J MGP_CBAJ_G0030096
 protein coding gene Chr6:447523-529255 (-)
DBA/2J MGP_DBA2J_G0030240
 protein coding gene Chr6:390684-471357 (-)
FVB/NJ MGP_FVBNJ_G0030194
 protein coding gene Chr6:404083-482145 (-)
LP/J MGP_LPJ_G0030327
 protein coding gene Chr6:407701-486178 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030230
 protein coding gene Chr6:463765-564833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030889
 protein coding gene Chr6:390943-467378 (-)
PWK/PhJ MGP_PWKPhJ_G0029234
 protein coding gene Chr6:335074-415300 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029070
 protein coding gene Chr6:413618-494532 (-)
WSB/EiJ MGP_WSBEiJ_G0029596
 protein coding gene Chr6:383266-465435 (-)



Homology
more
  • Human Ortholog
    CALCR, calcitonin receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CALCR, calcitonin receptor
  • Synonyms
    CRT, CT-R, CTR, CTR1
  • Links
    NCBI Gene ID: 799
    neXtProt AC: NX_P30988
    UniProt: P30988

  • Chr Location
    7q21.3; chr7:93424486-93574730 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CALCR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Haploinsufficiency may result in increased bone density due to increased bone formation. Homozygous inactivation may result in embryonic lethality. Mice homozygous for another disruption allele at this locus show a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    73
  • cDNA Data
    11
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023964 Ensembl Gene Model | MGI Sequence Detail 79035 C57BL/6J ±  kb
    transcript ENSMUST00000170266 Ensembl | MGI Sequence Detail 2175 Not Applicable  
    polypeptide ENSMUSP00000132124 Ensembl | MGI Sequence Detail 533 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004972 calcitonin receptor
      (term hierarchy)
    • InterPro Domains
      IPR001688 GPCR, family 2, calcitonin receptor
      IPR003287 GPCR, family 2, calcitonin receptor family
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      Q60755 4 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 11
      Primer pair 6
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18784
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 22
      Gene Ontology 11
      Phenotypes 34
    • Earliest
      J:22084 Yamin M, et al., Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Endocrinology. 1994 Dec;135(6):2635-43
    • Latest
      J:358802 Zhu W, et al., miR-148b-5p regulates hypercalciuria and calcium-containing nephrolithiasis. Cell Mol Life Sci. 2024 Aug 25;81(1):369
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory