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Pla2r1 Gene Detail
Summary
  • Symbol
    Pla2r1
  • Name
    phospholipase A2 receptor 1
  • Synonyms
    M-type receptor, Pla2g1br, PLA2-I receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:102468
    NCBI Gene: 18779
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:60247887-60383652 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 34.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3894 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102468
 protein coding gene Chr2:60247887-60383669 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025762
 protein coding gene Chr2:60013054-60155950 (-)
A/J MGP_AJ_G0025738
 protein coding gene Chr2:57699872-57836020 (-)
AKR/J MGP_AKRJ_G0025708
 protein coding gene Chr2:59289011-59430039 (-)
BALB/cJ MGP_BALBcJ_G0025733
 protein coding gene Chr2:57813750-57950726 (-)
C3H/HeJ MGP_C3HHeJ_G0025494
 protein coding gene Chr2:59384970-59527401 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026180
 protein coding gene Chr2:61773796-61919628 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023584
 protein coding gene Chr2:55273331-55410818 (-)
CAST/EiJ MGP_CASTEiJ_G0024958
 protein coding gene Chr2:59425342-59576871 (-)
CBA/J MGP_CBAJ_G0025474
 protein coding gene Chr2:64125924-64273810 (-)
DBA/2J MGP_DBA2J_G0025605
 protein coding gene Chr2:57298460-57432568 (-)
FVB/NJ MGP_FVBNJ_G0025567
 protein coding gene Chr2:56844841-56976204 (-)
LP/J MGP_LPJ_G0025693
 protein coding gene Chr2:59857273-59999024 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025598
 protein coding gene Chr2:65739147-65878939 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026237
 protein coding gene Chr2:59320594-59459019 (-)
PWK/PhJ MGP_PWKPhJ_G0024699
 protein coding gene Chr2:57157577-57295159 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024506
 protein coding gene Chr2:59380976-59531454 (-)
WSB/EiJ MGP_WSBEiJ_G0025026
 protein coding gene Chr2:59600669-59746050 (-)



Homology
more
  • Human Ortholog
    PLA2R1, phospholipase A2 receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2R1, phospholipase A2 receptor 1
  • Synonyms
    CLEC13C, PLA2G1R, PLA2IR, PLA2-R, PLA2R
  • Links
    NCBI Gene ID: 22925
    neXtProt AC: NX_Q13018
    UniProt: Q13018

  • Chr Location
    2q24.2; chr2:159923933-160062615 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable with no overt abnormalities. These mice are more resistant to toxic effects of lipopolysaccharide than controls, suggesting a role for this gene in the progression of endotoxic shock. Mice are more prone to spontaneously develop a wide spectrum or tumors with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    30
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054580 Ensembl Gene Model | MGI Sequence Detail 135766 C57BL/6J ±  kb
    transcript ENSMUST00000112525 Ensembl | MGI Sequence Detail 7112 Not Applicable  
    polypeptide ENSMUSP00000108144 Ensembl | MGI Sequence Detail 1487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19305
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:20932 Higashino K, et al., Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals. Eur J Biochem. 1994 Oct 1;225(1):375-82
    • Latest
      J:327694 Abi Nahed R, et al., Treatment of Mouse Sperm with a Non-Catalytic Mutant of PLA2G10 Reveals That PLA2G10 Improves In Vitro Fertilization through Both Its Enzymatic Activity and as Ligand of PLA2R1. Int J Mol Sci. 2022 Jul 21;23(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory