mt-Th MGI Mouse Gene Detail - MGI:102485 - mitochondrially encoded tRNA histidine

mt-Th Gene Detail

Symbol

mt-Th
Name

mitochondrially encoded tRNA histidine
Synonyms

tRNA, tRNA-His, TrnH tRNA

Feature Type

tRNA gene
IDs

MGI:102485
NCBI Gene: 17732
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

ChrMT:11546-11612 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome MT, Syntenic

SNPs within 2kb

34 from dbSNP Build 142
Strain Annotations

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102485	tRNA gene	ChrMT:11546-11612 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

TRNH, tRNA-His

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRNH, tRNA-His
Synonyms

MTTH
Links

HGNC:7487

NCBI Gene ID: 4564
Chr Location

chrMT:12138-12206 (+) GRCh38

MGI Vertebrate Homology

mt-Th stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: TRNH
Gene Tree

mt-Th

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References

1 with disease annotations

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Phenotype Summary

14 phenotype references

All Mutations and Alleles

1
Spontaneous

1
Genomic Mutations

1 involving mt-Th
Find Mice (IMSR)

0 strains or lines available

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All GO Annotations

3
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Other Mouse Links

Expression Atlas

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All Sequences

54

Ensembl

ENSMUSG00000064364 (Evidence)
NCBI Gene

17732

Representative Sequences				Length	Strain/Species	Flank
	genomic	17732	NCBI Gene Model \| MGI Sequence Detail	67	C57BL/6J	± kb

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All nucleic 52

Other 52

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MGD-MRK-19322

Summaries

All 26

Diseases 1

Gene Ontology 1

Phenotypes 14
Earliest

J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
Latest

J:303932 Ishikawa K, et al., Attempts to understand the mechanisms of mitochondrial diseases: The reverse genetics of mouse models for mitochondrial disease. Biochim Biophys Acta Gen Subj. 2021 Mar;1865(3):129835

TSS for mt-Th:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160168	ChrMT:11083-11106 (+)	-451 bp
Tssr160169	ChrMT:11108-11119 (+)	-432 bp
Tssr160170	ChrMT:11120-11134 (+)	-419 bp
Tssr160171	ChrMT:11172-11190 (+)	-365 bp
Tssr160172	ChrMT:11194-11230 (+)	-334 bp
Tssr160173	ChrMT:11241-11283 (+)	-284 bp
Tssr160174	ChrMT:11291-11305 (+)	-248 bp
Tssr160175	ChrMT:11323-11336 (+)	-216 bp
Tssr160176	ChrMT:11351-11362 (+)	-189 bp
Tssr160177	ChrMT:11371-11423 (+)	-149 bp
Tssr160178	ChrMT:11425-11457 (+)	-105 bp
Tssr160179	ChrMT:11459-11470 (+)	-81 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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