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mt-Nd6 Gene Detail
Summary
  • Symbol
    mt-Nd6
  • Name
    mitochondrially encoded NADH dehydrogenase 6
  • Synonyms
    ENSMUSG00000064368, URF6
  • Feature Type
    protein coding gene
  • IDs
    MGI:102495
    NCBI Gene: 17722
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrMT:13552-14070 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome MT, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102495
 protein coding gene ChrMT:13552-14070 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028393
 protein coding gene Chr4:79519116-79519628 (-)
A/J MGP_AJ_G0028354
 protein coding gene Chr4:76769483-76769983 (-)
AKR/J MGP_AKRJ_G0028304
 protein coding gene Chr4:78713529-78714029 (-)
BALB/cJ MGP_BALBcJ_G0028373
 protein coding gene Chr4:76983652-76984152 (-)
C3H/HeJ MGP_C3HHeJ_G0028089
 protein coding gene Chr4:79330547-79331047 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028813
 protein coding gene Chr4:82625944-82626462 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027530
 protein coding gene Chr4:77310943-77313720 (-)
CBA/J MGP_CBAJ_G0028058
 protein coding gene Chr4:85222190-85222690 (-)
DBA/2J MGP_DBA2J_G0028207
 protein coding gene Chr4:76519447-76519947 (-)
FVB/NJ MGP_FVBNJ_G0028173
 protein coding gene Chr4:75547155-75547673 (-)
LP/J MGP_LPJ_G0028307
 protein coding gene Chr4:79862824-79863336 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028202
 protein coding gene Chr4:90146511-90147029 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028850
 protein coding gene Chr4:78835538-78836135 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0027606
 protein coding gene Chr4:78951037-78951549 (-)



Homology
more
  • Human Ortholog
    ND6, NADH dehydrogenase subunit 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ND6, NADH dehydrogenase subunit 6
  • Synonyms
    MTND6
  • Links
    NCBI Gene ID: 4541
    neXtProt AC: NX_P03923
    UniProt: P03923

  • Chr Location
    chrMT:14149-14673 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with mt-Nd6 mouse models; 3 with human ND6 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    5 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homoplastic for mitochondria containing a point mutation allele exhibit decreased mitochondrial oxidation and elevated lactate serum levels. Mice with mitochondria containing an insertion exhibit decreased mitochondrial oxidation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    7
  • cDNA Data
    22
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      83
    • RefSeq
      1
    • UniProt
      4
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17722 NCBI Gene Model | MGI Sequence Detail 519 C57BL/6J ±  kb
    transcript BC055066 GenBank | ENA | DDBJ | MGI Sequence Detail 5623 C57BL/6J  
    polypeptide P03925 UniProt | EBI | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 22
      Primer pair 1
      Other 52

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-19332, MGI:2140439, MGI:2140440, MGI:2140446, MGI:2140451, MGI:2140454, MGI:2140456, MGI:2140458, MGI:2153793, MGI:3809053
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 7
      Diseases 4
      Gene Ontology 10
      Phenotypes 30
    • Earliest
      J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
    • Latest
      J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory