Crisp1 MGI Mouse Gene Detail - MGI:102553 - cysteine-rich secretory protein 1

Symbol

Crisp1
Name

cysteine-rich secretory protein 1
Synonyms

Aeg1, CRISP-1

Feature Type

protein coding gene
IDs

MGI:102553
NCBI Gene: 11571
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:40604649-40630098 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.47 cM
Mapping Data

3 experiments

SNPs within 2kb

837 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102553	protein coding gene	Chr17:40604649-40630098 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023753	protein coding gene	Chr17:41089442-41117744 (-)
A/J	MGP_AJ_G0023711	protein coding gene	Chr17:40162510-40188616 (-)
AKR/J	MGP_AKRJ_G0023683	protein coding gene	Chr17:40247775-40292162 (-)
BALB/cJ	MGP_BALBcJ_G0023714	protein coding gene	Chr17:40030954-40056682 (-)
C3H/HeJ	MGP_C3HHeJ_G0023480	protein coding gene	Chr17:40862784-40883344 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024157	protein coding gene	Chr17:42909279-42932566 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021611	protein coding gene	Chr17:37129490-37326678 (-)
CAST/EiJ	MGP_CASTEiJ_G0022960	protein coding gene	Chr17:41024667-41050829 (-)
CBA/J	MGP_CBAJ_G0023456	protein coding gene	Chr17:44394335-44440964 (-)
DBA/2J	MGP_DBA2J_G0023581	protein coding gene	Chr17:38974531-38996701 (-)
FVB/NJ	MGP_FVBNJ_G0023548	protein coding gene	Chr17:38567377-38608101 (-)
LP/J	MGP_LPJ_G0023662	protein coding gene	Chr17:41708598-41736199 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023576	protein coding gene	Chr17:43771863-43823790 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024203	protein coding gene	Chr17:40638399-40660579 (-)
PWK/PhJ	MGP_PWKPhJ_G0022704	protein coding gene	Chr17:38327207-38350002 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022522	protein coding gene	Chr17:37801864-37825644 (-)
WSB/EiJ	MGP_WSBEiJ_G0023025	protein coding gene	Chr17:41049074-41105497 (-)

Human Ortholog

CRISP3, cysteine rich secretory protein 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRISP3, cysteine rich secretory protein 3
Synonyms

Aeg2, CRISP-3, CRS3, dJ442L6.3, SGP28
Links

HGNC:16904

NCBI Gene ID: 10321

neXtProt AC: NX_P54108

UniProt: P54108
Chr Location

6p12.3; chr6:49727376-49744437 (-) GRCh38

MGI Vertebrate Homology

Crisp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CRISP3
Gene Tree

Crisp1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a null allele exhibit reduced ability of sperm to fertilize eggs but no reduction in fertility.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

6
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crisp1.3, crisp1.6, crisp1.7

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All Sequences

32
RefSeq

2
UniProt

3
CCDS

CCDS28784.1

Ensembl

ENSMUSG00000025431 (Evidence)
NCBI Gene

11571

			Length	Strain/Species	Flank
genomic	11571	NCBI Gene Model \| MGI Sequence Detail	25450	C57BL/6J	± kb
transcript	NM_009638	RefSeq \| MGI Sequence Detail	1416	ZRU/MplStud
polypeptide	Q03401	UniProt \| EBI \| MGI Sequence Detail	244	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005880 cysteine-rich secretory protein 3

(term hierarchy)
InterPro Domains

IPR018244 Allergen V5/Tpx-1-related, conserved site

IPR014044 CAP domain

IPR035940 CAP superfamily

IPR042076 Crisp-like domain

IPR013871 Cysteine-rich secretory protein

IPR001283 Cysteine-rich secretory protein-related

IPR034117 Cysteine-rich secretory protein, SCP domain

IPR003582 ShKT domain
GlyGen

Q03401 1 site

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All nucleic 24

Genomic 4

cDNA 18

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-19402, MGI:2147060

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 10
Earliest

J:3169 Mizuki N, et al., Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule. Mol Cell Endocrinol. 1992 Nov;89(1-2):25-32
Latest

J:311209 Gaikwad AS, et al., CRISPs Function to Boost Sperm Power Output and Motility. Front Cell Dev Biol. 2021;9:693258

TSS for Crisp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148085	Chr17:40630191-40630195 (-)	-95 bp
Tssr148084	Chr17:40630096-40630099 (-)	0 bp
Tssr148083	Chr17:40609109-40609118 (-)	20,984 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24