Pou3f3 MGI Mouse Gene Detail - MGI:102564 - POU domain, class 3, transcription factor 3

Symbol

Pou3f3
Name

POU domain, class 3, transcription factor 3
Synonyms

Brn-1, Brn1, HST011, Otf8, urehr2

Feature Type

protein coding gene
IDs

MGI:102564
NCBI Gene: 18993
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:42734928-42739370 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 21.21 cM
Mapping Data

3 experiments

SNPs within 2kb

82 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102564	protein coding gene	Chr1:42734085-42742336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015974	protein coding gene	Chr1:41644666-41653404 (+)
A/J	MGP_AJ_G0015958	protein coding gene	Chr1:40409808-40417360 (+)
AKR/J	MGP_AKRJ_G0015913	protein coding gene	Chr1:40921295-40928680 (+)
BALB/cJ	MGP_BALBcJ_G0015912	protein coding gene	Chr1:40068554-40076208 (+)
C3H/HeJ	MGP_C3HHeJ_G0015745	protein coding gene	Chr1:41300442-41308493 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016365	protein coding gene	Chr1:43367639-43376020 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014087	protein coding gene	Chr1:37236641-37244086 (+)
CAST/EiJ	MGP_CASTEiJ_G0015326	protein coding gene	Chr1:41280476-41288644 (+)
CBA/J	MGP_CBAJ_G0015717	protein coding gene	Chr1:44640242-44653515 (+)
DBA/2J	MGP_DBA2J_G0015818	protein coding gene	Chr1:39675989-39683785 (+)
FVB/NJ	MGP_FVBNJ_G0015820	protein coding gene	Chr1:39206861-39214059 (+)
LP/J	MGP_LPJ_G0015888	protein coding gene	Chr1:41987395-41994273 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015840	protein coding gene	Chr1:46622640-46630617 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016412	protein coding gene	Chr1:41124696-41135277 (+)
PWK/PhJ	MGP_PWKPhJ_G0015109	protein coding gene	Chr1:39539369-39547551 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014891	protein coding gene	Chr1:41124317-41132718 (+)
WSB/EiJ	MGP_WSBEiJ_G0015388	protein coding gene	Chr1:41164289-41174777 (+)

Human Ortholog

POU3F3, POU class 3 homeobox 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POU3F3, POU class 3 homeobox 3
Synonyms

brain-1, BRN1, oct-8, OTF8, SNIBFIS
Links

HGNC:9216

NCBI Gene ID: 5455

neXtProt AC: NX_P20264

UniProt: P20264
Chr Location

2q12.1; chr2:104853287-104858574 (+) GRCh38

MGI Vertebrate Homology

Pou3f3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: POU3F3
Protein SuperFamily

Transcription_factor_POU
Gene Tree

Pou3f3

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Phenotype Summary

26 phenotypes from 3 alleles in 3 genetic backgrounds
15 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

1 involving Pou3f3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in death within 36 hours after birth. Mutant brains exhibit disorganized cells in the hippocampus and adjacent transitional cortex.

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All GO Annotations

43
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1425
Tissues

317
cDNA Data

10
Literature Summary

110

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pou3f3

ZFIN pou3f3a, pou3f3b

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS14917.1

Ensembl

ENSMUSG00000045515 (Evidence)
NCBI Gene

18993

			Length	Strain/Species	Flank
genomic	18993	NCBI Gene Model \| MGI Sequence Detail	4443	C57BL/6J	± kb
transcript	NM_008900	RefSeq \| MGI Sequence Detail	4443	ZRU/MplStud
polypeptide	P31361	UniProt \| EBI \| MGI Sequence Detail	497	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031407 POU domain, class 3, transcription factor 3

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR010982 Lambda repressor-like, DNA-binding domain superfamily

IPR013847 POU domain

IPR050255 POU domain transcription factor

IPR016362 POU-domain transcription factor, class 3

IPR000327 POU-specific domain

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All nucleic 28

Genomic 3

cDNA 14

Primer pair 6

Other 5

Microarray probesets 3

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MGD-MRK-13083, MGD-MRK-1623, MGD-MRK-1627, MGD-MRK-19445, MGI:3712270

Summaries

All 151

Developmental Gene Expression 110

Gene Ontology 13

Phenotypes 12
Earliest

J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
Latest

J:354227 Barao S, et al., Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion. Nat Commun. 2024 Sep 14;15(1):8043

TSS for Pou3f3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6511	Chr1:42734874-42734881 (+)	-50 bp
Tssr6512	Chr1:42734889-42734936 (+)	-15 bp
Tssr6513	Chr1:42734969-42734980 (+)	47 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24