Nmt1 MGI Mouse Gene Detail - MGI:102579 - N-myristoyltransferase 1

Symbol

Nmt1
Name

N-myristoyltransferase 1

Feature Type

protein coding gene
IDs

MGI:102579
NCBI Gene: 18107
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:102919163-102959734 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.71 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

1176 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102579	protein coding gene	Chr11:102919016-102959738 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019253	protein coding gene	Chr11:106069412-106114247 (+)
A/J	MGP_AJ_G0019221	protein coding gene	Chr11:101574105-101619027 (+)
AKR/J	MGP_AKRJ_G0019190	protein coding gene	Chr11:104713372-104753913 (+)
BALB/cJ	MGP_BALBcJ_G0019195	protein coding gene	Chr11:102049413-102091751 (+)
C3H/HeJ	MGP_C3HHeJ_G0019004	protein coding gene	Chr11:104937668-104979518 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019644	protein coding gene	Chr11:109361851-109416613 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017270	protein coding gene	Chr11:98994386-99036349 (+)
CAST/EiJ	MGP_CASTEiJ_G0018558	protein coding gene	Chr11:105949510-105990799 (+)
CBA/J	MGP_CBAJ_G0018973	protein coding gene	Chr11:113908946-113965143 (+)
DBA/2J	MGP_DBA2J_G0019085	protein coding gene	Chr11:101091916-101131700 (+)
FVB/NJ	MGP_FVBNJ_G0019075	protein coding gene	Chr11:100634199-100673548 (+)
LP/J	MGP_LPJ_G0019154	protein coding gene	Chr11:106588612-106633129 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019106	protein coding gene	Chr11:113317460-113362037 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019682	protein coding gene	Chr11:105094416-105136563 (+)
PWK/PhJ	MGP_PWKPhJ_G0018321	protein coding gene	Chr11:102161020-102200413 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018113	protein coding gene	Chr11:104852654-104894461 (+)
WSB/EiJ	MGP_WSBEiJ_G0018607	protein coding gene	Chr11:105090053-105136856 (+)

Human Ortholog

NMT1, N-myristoyltransferase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NMT1, N-myristoyltransferase 1
Synonyms

HsNMT1, NMT
Links

HGNC:7857

NCBI Gene ID: 4836

neXtProt AC: NX_P30419

UniProt: P30419
Chr Location

17q21.31; chr17:44957992-45109016 (+) GRCh38

MGI Vertebrate Homology

Nmt1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NMT1
Protein SuperFamily

N-myristl_transf
Gene Tree

Nmt1

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Gene trapped

2
Targeted

4
Genomic Mutations

1 involving Nmt1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available

Homozygous mutation of this gene results in embryonic lethality between E3.5 and E7.5. Heterozygotes show partial prenatal lethality. Mice homozygous for a conditional allele knocked out in T cells exhibit reduced T cell, double positive T cell and single positive T cell numbers.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

27
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nmt1

ZFIN nmt1b

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All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS25511.1

Ensembl

ENSMUSG00000020936 (Evidence)
NCBI Gene

18107

			Length	Strain/Species	Flank
genomic	18107	NCBI Gene Model \| MGI Sequence Detail	40572	C57BL/6J	± kb
transcript	NM_008707	RefSeq \| MGI Sequence Detail	4660	C57BL/6
polypeptide	O70310	UniProt \| EBI \| MGI Sequence Detail	496	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000002203 glycylpeptide N-tetradecanoyltransferase 1

(term hierarchy)
EC

2.3.1.97
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR000903 Glycylpeptide N-tetradecanoyltransferase

IPR022678 Glycylpeptide N-tetradecanoyltransferase, conserved site

IPR022677 Glycylpeptide N-tetradecanoyltransferase, C-terminal

IPR022676 Glycylpeptide N-tetradecanoyltransferase, N-terminal
GlyGen

O70310 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 17

cDNA 13

Primer pair 3

Other 1

Microarray probesets 6

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MGD-MRK-19465, MGI:2144553

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 19
Earliest

J:19094 Hara T, et al., Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood. 1994 Jul 1;84(1):189-99
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Nmt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105296	Chr11:102918670-102918688 (+)	-484 bp
Tssr105297	Chr11:102919153-102919194 (+)	11 bp
Tssr105298	Chr11:102919368-102919399 (+)	221 bp
Tssr105299	Chr11:102933810-102933819 (+)	14,652 bp
Tssr105300	Chr11:102933839-102933860 (+)	14,687 bp
Tssr105301	Chr11:102933985-102934009 (+)	14,834 bp
Tssr105302	Chr11:102947704-102947717 (+)	28,548 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24