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Lhx3 Gene Detail
Summary
  • Symbol
    Lhx3
  • Name
    LIM homeobox protein 3
  • Synonyms
    Lim3, mLim-3, P-LIM
  • Feature Type
    protein coding gene
  • IDs
    MGI:102673
    NCBI Gene: 16871
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26090224-26098261 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 18.44 cM, cytoband A2-C1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    202 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102673
 protein coding gene Chr2:26090224-26098301 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025478
 protein coding gene Chr2:24151924-24159997 (-)
A/J MGP_AJ_G0025455
 protein coding gene Chr2:23217728-23225801 (-)
AKR/J MGP_AKRJ_G0025425
 protein coding gene Chr2:23973041-23981114 (-)
BALB/cJ MGP_BALBcJ_G0025451
 protein coding gene Chr2:23328860-23336937 (-)
C3H/HeJ MGP_C3HHeJ_G0025212
 protein coding gene Chr2:23932948-23941025 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025895
 protein coding gene Chr2:24923991-24932068 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023306
 protein coding gene Chr2:22100039-22108229 (-)
CAST/EiJ MGP_CASTEiJ_G0024675
 protein coding gene Chr2:23803093-23811152 (-)
CBA/J MGP_CBAJ_G0025190
 protein coding gene Chr2:25765561-25773638 (-)
DBA/2J MGP_DBA2J_G0025323
 protein coding gene Chr2:23043588-23051643 (-)
FVB/NJ MGP_FVBNJ_G0025285
 protein coding gene Chr2:22791670-22800236 (-)
LP/J MGP_LPJ_G0025409
 protein coding gene Chr2:24087325-24095402 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025316
 protein coding gene Chr2:25927908-25935985 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025954
 protein coding gene Chr2:23935444-23943574 (-)
PWK/PhJ MGP_PWKPhJ_G0024423
 protein coding gene Chr2:22842738-22850924 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024223
 protein coding gene Chr2:24064127-24072226 (-)
WSB/EiJ MGP_WSBEiJ_G0024744
 protein coding gene Chr2:24040931-24049010 (-)



Homology
more
  • Human Ortholog
    LHX3, LIM homeobox 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LHX3, LIM homeobox 3
  • Synonyms
    CPHD3, LIM3, M2-LHX3
  • Links
    NCBI Gene ID: 8022
    neXtProt AC: NX_Q9UBR4
    UniProt: Q9UBR4

  • Chr Location
    9q34.3; chr9:136196250-136205128 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lhx3 mouse models; 1 with human LHX3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit failure of growth and differentiation of Rathke's pouch, lack both anterior and intermediate lobes of the pituitary gland, and die perinatally, within 24 hours of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1360
  • Tissues
    316
  • cDNA Data
    28
  • Literature Summary
    202
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16871 NCBI Gene Model | MGI Sequence Detail 8038 C57BL/6J ±  kb
    transcript NM_001039653 RefSeq | MGI Sequence Detail 2241 ZRU/MplStud  
    polypeptide P50481 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 3
      cDNA 30
      Primer pair 7
      Other 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19576
    References
    more
    • Summaries
      All 264
      Developmental Gene Expression 202
      Diseases 1
      Gene Ontology 18
      Phenotypes 29
    • Earliest
      J:22277 Seidah NG, et al., The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary. DNA Cell Biol. 1994 Dec;13(12):1163-80
    • Latest
      J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory