Abcc1 MGI Mouse Gene Detail - MGI:102676 - ATP-binding cassette, sub-family C member 1

Symbol

Abcc1
Name

ATP-binding cassette, sub-family C member 1
Synonyms

Abcc1a, Abcc1b, Mdrap, MRP, Mrp1

Feature Type

protein coding gene
IDs

MGI:102676
NCBI Gene: 17250
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr16:14179317-14292743 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 9.75 cM
Mapping Data

2 experiments

SNPs within 2kb

2943 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102676	protein coding gene	Chr16:14179317-14293601 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022545	protein coding gene	Chr16:11408837-11533626 (+)
A/J	MGP_AJ_G0022507	protein coding gene	Chr16:10768469-10885622 (+)
AKR/J	MGP_AKRJ_G0022483	protein coding gene	Chr16:11248966-11369648 (+)
BALB/cJ	MGP_BALBcJ_G0022511	protein coding gene	Chr16:10942091-11065013 (+)
C3H/HeJ	MGP_C3HHeJ_G0022278	protein coding gene	Chr16:11340124-11462583 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022960	protein coding gene	Chr16:11570113-11694687 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020480	protein coding gene	Chr16:10889473-10991437 (+)
CAST/EiJ	MGP_CASTEiJ_G0021805	protein coding gene	Chr16:11380560-11500570 (+)
CBA/J	MGP_CBAJ_G0022247	protein coding gene	Chr16:12115028-12242596 (+)
DBA/2J	MGP_DBA2J_G0022378	protein coding gene	Chr16:10772736-10889682 (+)
FVB/NJ	MGP_FVBNJ_G0022354	protein coding gene	Chr16:10756005-10870575 (+)
LP/J	MGP_LPJ_G0022446	protein coding gene	Chr16:11301177-11425916 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022376	protein coding gene	Chr16:11743288-11861995 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022973	protein coding gene	Chr16:11210958-11336594 (+)
PWK/PhJ	MGP_PWKPhJ_G0021547	protein coding gene	Chr16:11027929-11142946 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021376	protein coding gene	Chr16:11186409-11311709 (+)
WSB/EiJ	MGP_WSBEiJ_G0021853	protein coding gene	Chr16:11232221-11355337 (+)

Human Ortholog

ABCC1, ATP binding cassette subfamily C member 1 (ABCC1 blood group)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABCC1, ATP binding cassette subfamily C member 1 (ABCC1 blood group)
Synonyms

ABC29, ABCC, DFNA77, GS-X, MRP, MRP1
Links

HGNC:51

NCBI Gene ID: 4363

neXtProt AC: NX_P33527

UniProt: P33527
Chr Location

16p13.11; chr16:15949138-16143257 (+) GRCh38

MGI Vertebrate Homology

Abcc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABCC1
Gene Tree

Abcc1

Diseases

2 with human ABCC1 associations

				Human Disease	Mouse Models
				autosomal dominant nonsyndromic deafness 77 IDs autosomal dominant nonsyndromic deafness 77 DOID:0112168 OMIM:618915
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

5
Gene trapped

11
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

76 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide.

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All GO Annotations

85
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

856
Tissues

137
cDNA Data

97
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ABCC1

Xenbase abcc1

ZFIN abcc1

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All Sequences

76
RefSeq

9
UniProt

10
CCDS

CCDS37264.1

Ensembl

ENSMUSG00000023088 (Evidence)
NCBI Gene

17250

			Length	Strain/Species	Flank
genomic	17250	NCBI Gene Model \| MGI Sequence Detail	113427	C57BL/6J	± kb
transcript	NM_008576	RefSeq \| MGI Sequence Detail	5915	C57BL/6
polypeptide	O35379	UniProt \| EBI \| MGI Sequence Detail	1528	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000003554 multidrug resistance-associated protein 1

(term hierarchy)
EC

7.6.2.2, 7.6.2.3
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR003439 ABC transporter-like, ATP-binding domain

IPR017871 ABC transporter-like, conserved site

IPR011527 ABC transporter type 1, transmembrane domain

IPR036640 ABC transporter type 1, transmembrane domain superfamily

IPR050173 ATP-binding cassette transporter C

IPR005292 Multi drug resistance-associated protein

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

O35379 2 sites

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All nucleic 102

Genomic 2

cDNA 98

Primer pair 2

Microarray probesets 5

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MGD-MRK-19579, MGI:2137380

Summaries

All 106

Developmental Gene Expression 8

Diseases 1

Gene Ontology 13

Phenotypes 46
Earliest

J:24061 Doggett NA, et al., Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994. Cytogenet Cell Genet. 1995;68(3-4):165-84
Latest

J:329937 Maltbaek JH, et al., ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. Immunity. 2022 Oct 11;55(10):1799-1812.e4

TSS for Abcc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137192	Chr16:14179310-14179315 (+)	-4 bp
Tssr137193	Chr16:14179416-14179465 (+)	124 bp
Tssr137194	Chr16:14183588-14183607 (+)	4,281 bp
Tssr137195	Chr16:14188841-14188856 (+)	9,532 bp
Tssr137196	Chr16:14191193-14191199 (+)	11,879 bp
Tssr137197	Chr16:14191488-14191514 (+)	12,184 bp
Tssr137198	Chr16:14207740-14207783 (+)	28,445 bp
Tssr137199	Chr16:14216143-14216159 (+)	36,834 bp
Tssr137200	Chr16:14221017-14221020 (+)	41,702 bp
Tssr137201	Chr16:14259157-14259177 (+)	79,850 bp
Tssr137202	Chr16:14269594-14269596 (+)	90,278 bp
Tssr137203	Chr16:14276478-14276488 (+)	97,166 bp
Tssr137204	Chr16:14289900-14289915 (+)	110,591 bp
Tssr137205	Chr16:14291482-14291511 (+)	112,180 bp
Tssr137206	Chr16:14292160-14292200 (+)	112,863 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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