Cdc27 MGI Mouse Gene Detail - MGI:102685

Symbol

Cdc27
Name

cell division cycle 27
Synonyms

APC3

Feature Type

protein coding gene
IDs

MGI:102685
NCBI Gene: 217232
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:104393571-104441446 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 67.79 cM
Mapping Data

3 experiments

SNPs within 2kb

1321 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102685	protein coding gene	Chr11:104393350-104441446 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019276	protein coding gene	Chr11:107661649-107709603 (-)
A/J	MGP_AJ_G0019244	protein coding gene	Chr11:103082252-103130636 (-)
AKR/J	MGP_AKRJ_G0019213	protein coding gene	Chr11:106227602-106275463 (-)
BALB/cJ	MGP_BALBcJ_G0019218	protein coding gene	Chr11:103513858-103562243 (-)
C3H/HeJ	MGP_C3HHeJ_G0019027	protein coding gene	Chr11:106469822-106518612 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019668	protein coding gene	Chr11:110982319-111042040 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017293	protein coding gene	Chr11:100471643-100520068 (-)
CAST/EiJ	MGP_CASTEiJ_G0018581	protein coding gene	Chr11:107529585-107579324 (-)
CBA/J	MGP_CBAJ_G0018996	protein coding gene	Chr11:115592604-115643886 (-)
DBA/2J	MGP_DBA2J_G0019108	protein coding gene	Chr11:102567059-102616654 (-)
FVB/NJ	MGP_FVBNJ_G0019099	protein coding gene	Chr11:102105884-102154144 (-)
LP/J	MGP_LPJ_G0019177	protein coding gene	Chr11:108135730-108185957 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019129	protein coding gene	Chr11:114911141-114962760 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019705	protein coding gene	Chr11:106628015-106678762 (-)
PWK/PhJ	MGP_PWKPhJ_G0018346	protein coding gene	Chr11:103673161-103722241 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018136	protein coding gene	Chr11:106399629-106450336 (-)
WSB/EiJ	MGP_WSBEiJ_G0018630	protein coding gene	Chr11:106641698-106690011 (-)

Human Ortholog

CDC27, cell division cycle 27

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDC27, cell division cycle 27
Synonyms

ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2
Links

HGNC:1728

NCBI Gene ID: 996

neXtProt AC: NX_P30260

UniProt: P30260
Chr Location

17q21.32; chr17:47117703-47189422 (-) GRCh38

MGI Vertebrate Homology

Cdc27 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDC27
Gene Tree

Cdc27

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

2
Gene trapped

15
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout is early embryonic lethal.

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All GO Annotations

30
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

9
cDNA Data

18
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDC27

Xenbase cdc27

ZFIN cdc27

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All Sequences

81
RefSeq

24
UniProt

5
CCDS

CCDS36354.1

Ensembl

ENSMUSG00000020687 (Evidence)
NCBI Gene

217232

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020687	Ensembl Gene Model \| MGI Sequence Detail	47876	C57BL/6J	± kb
transcript	ENSMUST00000106962	Ensembl \| MGI Sequence Detail	3160	Not Applicable
polypeptide	ENSMUSP00000102575	Ensembl \| MGI Sequence Detail	831	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005195 cell division cycle protein 27

(term hierarchy)
InterPro Domains

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 8

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MGD-MRK-19588, MGI:2144178, MGI:2384954

Summaries

All 52

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 12
Earliest

J:24091 Tugendreich S, et al., Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10031-5
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdc27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111254	Chr11:104441442-104441449 (-)	0 bp
Tssr111253	Chr11:104441412-104441416 (-)	32 bp
Tssr111252	Chr11:104441286-104441386 (-)	110 bp
Tssr111251	Chr11:104441236-104441245 (-)	205 bp
Tssr111250	Chr11:104436748-104436753 (-)	4,695 bp
Tssr111249	Chr11:104394503-104394551 (-)	46,919 bp
Tssr111248	Chr11:104394334-104394362 (-)	47,098 bp
Tssr111247	Chr11:104394268-104394271 (-)	47,176 bp
Tssr111246	Chr11:104394058-104394079 (-)	47,377 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24