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Bcl2a1a Gene Detail
Summary
  • Symbol
    Bcl2a1a
  • Name
    B cell leukemia/lymphoma 2 related protein A1a
  • Synonyms
    A1, Bcl2a1, Bfl-1, Hbpa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102687
    NCBI Gene: 12044
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:88838973-88844469 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 47.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    8
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102687
 protein coding gene Chr9:88838953-88844472 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0035025
 protein coding gene Chr9:88558210-88570133 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0034795
 protein coding gene Chr9:89238975-89239970 (+)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0034926
 protein coding gene Chr9:86020950-86032261 (-)
FVB/NJ MGP_FVBNJ_G0034870
 protein coding gene Chr9:85079882-85084915 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0034913
 protein coding gene Chr9:97456356-97472991 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0033816
 protein coding gene Chr9:86706654-86719974 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0034230
 protein coding gene Chr9:89143992-89149671 (+)



Homology
more
  • Human Ortholog
    BCL2A1, BCL2 related protein A1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL2A1, BCL2 related protein A1
  • Synonyms
    ACC-1, ACC1, ACC-2, ACC2, BCL2L5, BFL1, GRS, HBPA1
  • Links
    NCBI Gene ID: 597
    neXtProt AC: NX_Q16548
    UniProt: Q16548

  • Chr Location
    15q25.1; chr15:79960892-79971196 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show enhanced spontaneous apoptosis of neutrophils, while both heterozygous and homozygous null mutants lack LPS-induced neutrophil apoptosis inhibition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1181
  • Tissues
    182
  • cDNA Data
    7
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12044 NCBI Gene Model | MGI Sequence Detail 5497 C57BL/6J ±  kb
transcript NM_009742 RefSeq | MGI Sequence Detail 796 ZRU/MplStud  
polypeptide Q07440 UniProt | EBI | MGI Sequence Detail 172 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 3
    cDNA 9
    Primer pair 3
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-18735, MGD-MRK-19590, MGI:2143372
References
more
  • Summaries
    All 63
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:22455 Lin EY, et al., Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J Immunol. 1993 Aug 15;151(4):1979-88
  • Latest
    J:287191 Tan L, et al., Single-Cell Transcriptomics Identifies the Adaptation of Scart1(+) Vgamma6(+) T Cells to Skin Residency as Activated Effector Cells. Cell Rep. 2019 Jun 18;27(12):3657-3671.e4
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory