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H2ax Gene Detail
Summary
  • Symbol
    H2ax
  • Name
    H2A.X variant histone
  • Synonyms
    gammaH2ax, H2afx, H2A.X, Hist5-2ax
  • Feature Type
    protein coding gene
  • IDs
    MGI:102688
    NCBI Gene: 15270
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44246012-44247374 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102688
 protein coding gene Chr9:44245991-44247374 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034702
 protein coding gene Chr9:42817656-42820496 (+)
A/J MGP_AJ_G0034683
 protein coding gene Chr9:41629144-41630527 (+)
AKR/J MGP_AKRJ_G0034609
 protein coding gene Chr9:42488099-42489482 (+)
BALB/cJ MGP_BALBcJ_G0034674
 protein coding gene Chr9:41376751-41378134 (+)
C3H/HeJ MGP_C3HHeJ_G0034385
 protein coding gene Chr9:42945436-42948371 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035195
 protein coding gene Chr9:44091400-44093275 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032110
 protein coding gene Chr9:41207480-41208859 (+)
CAST/EiJ MGP_CASTEiJ_G0033707
 protein coding gene Chr9:42788932-42790315 (+)
CBA/J MGP_CBAJ_G0034357
 protein coding gene Chr9:45693963-45696103 (+)
DBA/2J MGP_DBA2J_G0034516
 protein coding gene Chr9:41530130-41532448 (+)
FVB/NJ MGP_FVBNJ_G0034457
 protein coding gene Chr9:40784622-40785863 (+)
LP/J MGP_LPJ_G0034597
 protein coding gene Chr9:43116673-43119375 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034501
 protein coding gene Chr9:47539259-47540642 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035216
 protein coding gene Chr9:42386934-42389194 (+)
PWK/PhJ MGP_PWKPhJ_G0033413
 protein coding gene Chr9:41401898-41403281 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033247
 protein coding gene Chr9:42708259-42709641 (+)
WSB/EiJ MGP_WSBEiJ_G0033820
 protein coding gene Chr9:42427277-42429463 (+)



Homology
more
  • Human Ortholog
    H2AX, H2A.X variant histone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H2AX, H2A.X variant histone
  • Synonyms
    H2AFX, H2A.X, H2A/X
  • Links
    NCBI Gene ID: 3014
    neXtProt AC: NX_P16104
    UniProt: P16104

  • Chr Location
    11q23.3; chr11:119093874-119095465 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are smaller and display increased susceptibility to ionizing radiation, male infertility, T and B cell abnormalities, and increased genomic instability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    52
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1230
  • Tissues
    124
  • cDNA Data
    90
  • Literature Summary
    354
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15270 NCBI Gene Model | MGI Sequence Detail 1363 C57BL/6J ±  kb
    transcript NM_010436 RefSeq | MGI Sequence Detail 1414 FVB/N  
    polypeptide P27661 UniProt | EBI | MGI Sequence Detail 143 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 3
      cDNA 93
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-19571, MGD-MRK-19591, MGI:2143303, MGI:6358820
    References
    more
    • Summaries
      All 526
      Developmental Gene Expression 354
      Gene Ontology 52
      Phenotypes 55
    • Earliest
      J:11221 Nagata T, et al., Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene. Nucleic Acids Res. 1991 May 11;19(9):2441-7
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory