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Srm Gene Detail
Summary
  • Symbol
    Srm
  • Name
    spermidine synthase
  • Synonyms
    SpdST, SpdSy
  • Feature Type
    protein coding gene
  • IDs
    MGI:102690
    NCBI Gene: 20810
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148675970-148679076 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102690
 protein coding gene Chr4:148675960-148679450 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029127
 protein coding gene Chr4:152330425-152333921 (+)
A/J MGP_AJ_G0029092
 protein coding gene Chr4:146027460-146030966 (+)
AKR/J MGP_AKRJ_G0029040
 protein coding gene Chr4:149999907-150003403 (+)
BALB/cJ MGP_BALBcJ_G0029108
 protein coding gene Chr4:146528464-146531970 (+)
C3H/HeJ MGP_C3HHeJ_G0028829
 protein coding gene Chr4:150562519-150566015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029557
 protein coding gene Chr4:157856821-157860311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026803
 protein coding gene Chr4:138442688-138446125 (+)
CAST/EiJ MGP_CASTEiJ_G0028242
 protein coding gene Chr4:147770774-147774271 (+)
CBA/J MGP_CBAJ_G0028791
 protein coding gene Chr4:162453288-162456685 (+)
DBA/2J MGP_DBA2J_G0028940
 protein coding gene Chr4:146130458-146133954 (+)
FVB/NJ MGP_FVBNJ_G0028904
 protein coding gene Chr4:145223859-145227349 (+)
LP/J MGP_LPJ_G0029030
 protein coding gene Chr4:152286473-152289969 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028931
 protein coding gene Chr4:165753803-165757304 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029589
 protein coding gene Chr4:150492890-150496386 (+)
PWK/PhJ MGP_PWKPhJ_G0027962
 protein coding gene Chr4:142121888-142125389 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027796
 protein coding gene Chr4:144742657-144746159 (+)
WSB/EiJ MGP_WSBEiJ_G0028322
 protein coding gene Chr4:150655110-150658606 (+)



Homology
more
  • Human Ortholog
    SRM, spermidine synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRM, spermidine synthase
  • Synonyms
    PAPT, SPDSY, SPS1, SRML1
  • Links
    NCBI Gene ID: 6723
    neXtProt AC: NX_P19623
    UniProt: P19623

  • Chr Location
    1p36.22; chr1:11054584-11060020 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    101
  • cDNA Data
    124
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20810 NCBI Gene Model | MGI Sequence Detail 3107 C57BL/6J ±  kb
transcript NM_009272 RefSeq | MGI Sequence Detail 1328 C57BL/6  
polypeptide Q64674 UniProt | EBI | MGI Sequence Detail 302 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 125
    cDNA 124
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-19593, MGI:2140122
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:36968 Kauppinen L, et al., Transgenic mice over-expressing the human spermidine synthase gene. Biochem J. 1993 Jul 15;293(Pt 2):513-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory