Efna2 MGI Mouse Gene Detail - MGI:102707

Symbol

Efna2
Name

ephrin A2
Synonyms

Cek7-L, Elf-1, Ephrin-A2, ephrin A6, Epl6, LERK-6

Feature Type

protein coding gene
IDs

MGI:102707
NCBI Gene: 13637
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:80015316-80025844 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

SNPs within 2kb

252 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102707	protein coding gene	Chr10:80015316-80025844 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017488	protein coding gene	Chr10:80766611-80777205 (+)
A/J	MGP_AJ_G0017466	protein coding gene	Chr10:77941917-77952445 (+)
AKR/J	MGP_AKRJ_G0017427	protein coding gene	Chr10:80072315-80082843 (+)
BALB/cJ	MGP_BALBcJ_G0017428	protein coding gene	Chr10:78165466-78176003 (+)
C3H/HeJ	MGP_C3HHeJ_G0017251	protein coding gene	Chr10:80168486-80179001 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017882	protein coding gene	Chr10:83548099-83558619 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015570	protein coding gene	Chr10:74167665-74178149 (+)
CAST/EiJ	MGP_CASTEiJ_G0016818	protein coding gene	Chr10:80373347-80383882 (+)
CBA/J	MGP_CBAJ_G0017223	protein coding gene	Chr10:86790203-86800717 (+)
DBA/2J	MGP_DBA2J_G0017329	protein coding gene	Chr10:77163310-77173849 (+)
FVB/NJ	MGP_FVBNJ_G0017323	protein coding gene	Chr10:76346336-76357052 (+)
LP/J	MGP_LPJ_G0017400	protein coding gene	Chr10:81245186-81255760 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017349	protein coding gene	Chr10:88739550-88751059 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017923	protein coding gene	Chr10:80051016-80062996 (+)
PWK/PhJ	MGP_PWKPhJ_G0016599	protein coding gene	Chr10:77027017-77037614 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016388	protein coding gene	Chr10:79032974-79043494 (+)
WSB/EiJ	MGP_WSBEiJ_G0016878	protein coding gene	Chr10:80087588-80098138 (+)

Human Ortholog

EFNA2, ephrin A2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EFNA2, ephrin A2
Synonyms

ELF-1, EPLG6, HEK7-L, LERK-6, LERK6
Links

HGNC:3222

NCBI Gene ID: 1943

neXtProt AC: NX_O43921

UniProt: O43921
Chr Location

19p13.3; chr19:1284227-1301431 (+) GRCh38

MGI Vertebrate Homology

Efna2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EFNA2
Gene Tree

Efna2

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

8
Targeted

5
Genomic Mutations

1 involving Efna2
Incidental Mutations

CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozgous null mice exhibit increased neural progenitor cell proliferation and abnormalities in sensory projections to the superior colliculus

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

956
Tissues

196
cDNA Data

33
Literature Summary

60

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase efna2

ZFIN efna2a

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS24013.1

Ensembl

ENSMUSG00000003070 (Evidence)
NCBI Gene

13637

			Length	Strain/Species	Flank
genomic	13637	NCBI Gene Model \| MGI Sequence Detail	10529	C57BL/6J	± kb
transcript	NM_007909	RefSeq \| MGI Sequence Detail	2153	ZRU/MplStud
polypeptide	P52801	UniProt \| EBI \| MGI Sequence Detail	209	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006917 ephrin-A2

(term hierarchy)
InterPro Domains

IPR008972 Cupredoxin

IPR031328 Ephrin

IPR034252 Ephrin-A ectodomain

IPR019765 Ephrin, conserved site

IPR001799 Ephrin receptor-binding domain
GlyGen

P52801 3 sites, 1 N-linked glycan (1 site)

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All nucleic 41

cDNA 33

Primer pair 4

Other 4

Microarray probesets 4

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MGD-MRK-19611

Summaries

All 140

Developmental Gene Expression 60

Diseases 1

Gene Ontology 9

Phenotypes 50
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Efna2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94519	Chr10:80015265-80015298 (+)	-34 bp
Tssr94520	Chr10:80015327-80015365 (+)	30 bp
Tssr94521	Chr10:80015522-80015589 (+)	240 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24