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Vav2 Gene Detail
Summary
  • Symbol
    Vav2
  • Name
    vav 2 oncogene
  • Synonyms
    2810040F13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:102718
    NCBI Gene: 22325
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27152116-27317045 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.36 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4935 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102718
 protein coding gene Chr2:27152116-27317620 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025513
 protein coding gene Chr2:25239175-25410694 (-)
A/J MGP_AJ_G0025490
 protein coding gene Chr2:24288568-24459373 (-)
AKR/J MGP_AKRJ_G0025460
 protein coding gene Chr2:25086550-25253949 (-)
BALB/cJ MGP_BALBcJ_G0025486
 protein coding gene Chr2:24408232-24577059 (-)
C3H/HeJ MGP_C3HHeJ_G0025247
 protein coding gene Chr2:25020165-25188052 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025930
 protein coding gene Chr2:26090574-26269302 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023341
 protein coding gene Chr2:23119976-23283839 (-)
CAST/EiJ MGP_CASTEiJ_G0024710
 protein coding gene Chr2:24897660-25067039 (-)
CBA/J MGP_CBAJ_G0025225
 protein coding gene Chr2:27002141-27184003 (-)
DBA/2J MGP_DBA2J_G0025358
 protein coding gene Chr2:24109675-24276040 (-)
FVB/NJ MGP_FVBNJ_G0025320
 protein coding gene Chr2:23869739-24037729 (-)
LP/J MGP_LPJ_G0025444
 protein coding gene Chr2:25185041-25356654 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025351
 protein coding gene Chr2:27036468-27207985 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025989
 protein coding gene Chr2:25017667-25184671 (-)
PWK/PhJ MGP_PWKPhJ_G0024458
 protein coding gene Chr2:23901230-24068836 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024258
 protein coding gene Chr2:25166495-25336239 (-)
WSB/EiJ MGP_WSBEiJ_G0024779
 protein coding gene Chr2:25133975-25304836 (-)



Homology
more
  • Human Ortholog
    VAV2, vav guanine nucleotide exchange factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VAV2, vav guanine nucleotide exchange factor 2
  • Synonyms
    VAV-2
  • Links
    NCBI Gene ID: 7410
    neXtProt AC: NX_P52735
    UniProt: P52735

  • Chr Location
    9q34.2; chr9:133761894-133992604 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 2 alleles in 3 genetic backgrounds
    67 phenotypes from multigenic genotypes
    3 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants have defects in humoral immune response to type II thymus-independent antigens, in primary response to thymus-dependent antigens and inability to switch immunoglobulin class, form germinal centers and generate secondary responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    69
  • cDNA Data
    101
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009621 Ensembl Gene Model | MGI Sequence Detail 164930 C57BL/6J ±  kb
    transcript ENSMUST00000056176 Ensembl | MGI Sequence Detail 5221 Not Applicable  
    polypeptide ENSMUSP00000062782 Ensembl | MGI Sequence Detail 868 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 101
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19622, MGI:1919946, MGI:2139071
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 7
      Phenotypes 69
    • Earliest
      J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
    • Latest
      J:342516 Lorenzo-Martin LF, et al., The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome. Front Cell Dev Biol. 2023;11:1252834
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory