Guca2a MGI Mouse Gene Detail - MGI:102738 - guanylate cyclase activator 2a (guanylin)

Symbol

Guca2a
Name

guanylate cyclase activator 2a (guanylin)
Synonyms

Guca2

Feature Type

protein coding gene
IDs

MGI:102738
NCBI Gene: 14915
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr4:119494929-119496662 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 55.47 cM
Mapping Data

4 experiments

SNPs within 2kb

158 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102738	protein coding gene	Chr4:119494901-119496668 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028703	protein coding gene	Chr4:120847600-120849450 (+)
A/J	MGP_AJ_G0028663	protein coding gene	Chr4:116099396-116102738 (+)
AKR/J	MGP_AKRJ_G0028616	protein coding gene	Chr4:118631534-118633306 (+)
BALB/cJ	MGP_BALBcJ_G0028686	protein coding gene	Chr4:116729616-116731605 (+)
C3H/HeJ	MGP_C3HHeJ_G0028401	protein coding gene	Chr4:120189644-120191422 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029127	protein coding gene	Chr4:125434703-125436474 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026404	protein coding gene	Chr4:110194701-110196434 (+)
CAST/EiJ	MGP_CASTEiJ_G0027832	protein coding gene	Chr4:117511393-117513157 (+)
CBA/J	MGP_CBAJ_G0028368	protein coding gene	Chr4:128834419-128836807 (+)
DBA/2J	MGP_DBA2J_G0028515	protein coding gene	Chr4:116688444-116691644 (+)
FVB/NJ	MGP_FVBNJ_G0028481	protein coding gene	Chr4:115207583-115209351 (+)
LP/J	MGP_LPJ_G0028615	protein coding gene	Chr4:120973248-120975006 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028509	protein coding gene	Chr4:133718596-133720369 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029164	protein coding gene	Chr4:119699237-119701005 (+)
PWK/PhJ	MGP_PWKPhJ_G0027555	protein coding gene	Chr4:113618246-113620007 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027381	protein coding gene	Chr4:116141500-116143247 (+)
WSB/EiJ	MGP_WSBEiJ_G0027912	protein coding gene	Chr4:119710394-119712171 (+)

Human Ortholog

GUCA2A, guanylate cyclase activator 2A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GUCA2A, guanylate cyclase activator 2A
Synonyms

GCAP-I, GUCA2, STARA
Links

HGNC:4682

NCBI Gene ID: 2980

neXtProt AC: NX_Q02747

UniProt: Q02747
Chr Location

1p34.2; chr1:42162690-42164745 (-) GRCh38

MGI Vertebrate Homology

Guca2a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GUCA2A
Protein SuperFamily

Guanylin
Gene Tree

Guca2a

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

9
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Guca2a
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in increased proliferation and migration rate of colonic epithelia.

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

795
Tissues

11
cDNA Data

78
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS18586.1

Ensembl

ENSMUSG00000023247 (Evidence)
NCBI Gene

14915

			Length	Strain/Species	Flank
genomic	14915	NCBI Gene Model \| MGI Sequence Detail	1734	C57BL/6J	± kb
transcript	NM_008190	RefSeq \| MGI Sequence Detail	560	ZRU/MplStud
polypeptide	P33680	UniProt \| EBI \| MGI Sequence Detail	116	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008346 guanylin

(term hierarchy)
InterPro Domains

IPR000879 Guanylin

IPR036382 Guanylin superfamily

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All nucleic 80

Genomic 2

cDNA 78

Microarray probesets 3

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MGD-MRK-19643

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 17
Earliest

J:22330 Sciaky D, et al., Genomic sequence of the murine guanylin gene. Genomics. 1994 Dec;24(3):583-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Guca2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38747	Chr4:119494889-119494894 (+)	-37 bp
Tssr38748	Chr4:119494901-119494918 (+)	-19 bp
Tssr38749	Chr4:119494924-119494936 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24