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Nelfe Gene Detail
Summary
  • Symbol
    Nelfe
  • Name
    negative elongation factor complex member E, Rdbp
  • Synonyms
    NELF-E, Rdbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:102744
    NCBI Gene: 27632
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35069367-35075348 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102744
 protein coding gene Chr17:35069367-35075348 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023592
 protein coding gene Chr17:34962208-34968189 (+)
A/J MGP_AJ_G0023554
 protein coding gene Chr17:33820576-33826580 (+)
AKR/J MGP_AKRJ_G0023520
 protein coding gene Chr17:34279447-34285452 (+)
BALB/cJ MGP_BALBcJ_G0023559
 protein coding gene Chr17:33950888-33956892 (+)
C3H/HeJ MGP_C3HHeJ_G0023319
 protein coding gene Chr17:34678818-34685690 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023999
 protein coding gene Chr17:36299518-36305499 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021478
 protein coding gene Chr17:31585054-31591267 (+)
CAST/EiJ MGP_CASTEiJ_G0022817
 protein coding gene Chr17:34674564-34680563 (+)
CBA/J MGP_CBAJ_G0023297
 protein coding gene Chr17:37811066-37817071 (+)
DBA/2J MGP_DBA2J_G0023425
 protein coding gene Chr17:33134932-33140936 (+)
FVB/NJ MGP_FVBNJ_G0023392
 protein coding gene Chr17:32965180-32971184 (+)
LP/J MGP_LPJ_G0023502
 protein coding gene Chr17:35273064-35279045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023415
 protein coding gene Chr17:36739818-36745827 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024041
 protein coding gene Chr17:34509351-34515333 (+)
PWK/PhJ MGP_PWKPhJ_G0022566
 protein coding gene Chr17:31964508-31970590 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022383
 protein coding gene Chr17:32510528-32516523 (+)
WSB/EiJ MGP_WSBEiJ_G0022879
 protein coding gene Chr17:34618081-34624072 (+)



Homology
more
  • Human Ortholog
    NELFE, negative elongation factor complex member E
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NELFE, negative elongation factor complex member E
  • Synonyms
    D6S45, NELF-E, RD, RDBP, RDP
  • Links
    NCBI Gene ID: 7936
    neXtProt AC: NX_P18615
    UniProt: P18615

  • Chr Location
    6p21.33; chr6:31952087-31959038 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    22
  • cDNA Data
    12
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27632 NCBI Gene Model | MGI Sequence Detail 5982 C57BL/6J ±  kb
transcript NM_001045864 RefSeq | MGI Sequence Detail 1621 ZRU/MplStud  
polypeptide P19426 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013847 negative elongation factor E
    (term hierarchy)
  • InterPro Domains
    IPR033102 Negative elongation factor E
    IPR034637 Negative elongation factor E, RNA recognition motif
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
  • GlyGen
    P19426 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 19
    Genomic 5
    cDNA 12
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-19649
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:9107 Levi-Strauss M, et al., A previously undetected MHC gene with an unusual periodic structure. Science. 1988 Apr 8;240(4849):201-4
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory