Trim25 MGI Mouse Gene Detail - MGI:102749 - tripartite motif-containing 25

Symbol

Trim25
Name

tripartite motif-containing 25
Synonyms

estrogen-responsive finger protein, Zfp147

Feature Type

protein coding gene
IDs

MGI:102749
NCBI Gene: 217069
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:88890202-88911119 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 54.34 cM, cytoband C
Mapping Data

4 experiments

SNPs within 2kb

380 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102749	protein coding gene	Chr11:88890194-88911119 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018929	protein coding gene	Chr11:90764972-90785731 (+)
A/J	MGP_AJ_G0018897	protein coding gene	Chr11:87225016-87245786 (+)
AKR/J	MGP_AKRJ_G0018867	protein coding gene	Chr11:89901964-89922745 (+)
BALB/cJ	MGP_BALBcJ_G0018870	protein coding gene	Chr11:87643795-87664908 (+)
C3H/HeJ	MGP_C3HHeJ_G0018684	protein coding gene	Chr11:89911919-89941315 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019322	protein coding gene	Chr11:93552610-93575548 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016953	protein coding gene	Chr11:84247322-84267720 (+)
CAST/EiJ	MGP_CASTEiJ_G0018239	protein coding gene	Chr11:90627374-90649884 (+)
CBA/J	MGP_CBAJ_G0018655	protein coding gene	Chr11:97524425-97551920 (+)
DBA/2J	MGP_DBA2J_G0018763	protein coding gene	Chr11:86772069-86792797 (+)
FVB/NJ	MGP_FVBNJ_G0018752	protein coding gene	Chr11:86277779-86298980 (+)
LP/J	MGP_LPJ_G0018833	protein coding gene	Chr11:91287823-91308350 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018779	protein coding gene	Chr11:97437585-97458348 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019362	protein coding gene	Chr11:90101054-90124544 (+)
PWK/PhJ	MGP_PWKPhJ_G0018009	protein coding gene	Chr11:87632531-87658899 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017799	protein coding gene	Chr11:89683752-89704341 (+)
WSB/EiJ	MGP_WSBEiJ_G0018288	protein coding gene	Chr11:89994140-90014832 (+)

Human Ortholog

TRIM25, tripartite motif containing 25

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM25, tripartite motif containing 25
Synonyms

EFP, RNF147, Z147, ZNF147
Links

HGNC:12932

NCBI Gene ID: 7706

neXtProt AC: NX_Q14258

UniProt: Q14258
Chr Location

17q22; chr17:56836387-56914080 (-) GRCh38

MGI Vertebrate Homology

Trim25 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRIM25
Gene Tree

Trim25

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

7
Targeted

9
Genomic Mutations

4 involving Trim25
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Engineered mutations result in a compromised response to estrogen resulting in functional but small uteri.

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All GO Annotations

54
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1064
Tissues

231
cDNA Data

102
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim25

ZFIN trim25

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All Sequences

53
RefSeq

4
UniProt

9
CCDS

CCDS36278.1

Ensembl

ENSMUSG00000000275 (Evidence)
NCBI Gene

217069

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000275	Ensembl Gene Model \| MGI Sequence Detail	20918	C57BL/6J	± kb
transcript	ENSMUST00000107896	Ensembl \| MGI Sequence Detail	5590	Not Applicable
polypeptide	ENSMUSP00000103528	Ensembl \| MGI Sequence Detail	634	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000016650 E3 ubiquitin/ISG15 ligase TRIM25

(term hierarchy)
PDB

4B8E
EC

2.3.2.27, 6.3.2.n3
InterPro Domains

IPR001870 B30.2/SPRY domain

IPR043136 B30.2/SPRY domain superfamily

IPR003879 Butyrophylin-like, SPRY domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR051051 E3 ubiquitin-protein ligase TRIM/RNF

IPR006574 SPRY-associated

IPR003877 SPRY domain

IPR042753 TRIM25, PRY/SPRY domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR027370 Zinc finger, RING-type, eukaryotic
GlyGen

Q61510 1 site, 1 N-linked glycan (1 site)

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All nucleic 109

Genomic 2

cDNA 102

Primer pair 4

Other 1

Microarray probesets 5

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MGD-MRK-19654, MGI:2144055, MGI:2144339

Summaries

All 72

Developmental Gene Expression 6

Diseases 1

Gene Ontology 9

Phenotypes 25
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trim25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104062	Chr11:88890211-88890260 (+)	34 bp
Tssr104063	Chr11:88890268-88890305 (+)	85 bp
Tssr104064	Chr11:88895597-88895609 (+)	5,401 bp
Tssr104065	Chr11:88898942-88898955 (+)	8,747 bp
Tssr104066	Chr11:88901719-88901735 (+)	11,525 bp
Tssr104067	Chr11:88901795-88901803 (+)	11,597 bp
Tssr104068	Chr11:88906354-88906382 (+)	16,166 bp
Tssr104069	Chr11:88907703-88907719 (+)	17,509 bp
Tssr104070	Chr11:88907759-88907774 (+)	17,565 bp
Tssr104071	Chr11:88910305-88910327 (+)	20,114 bp
Tssr104072	Chr11:88910434-88910446 (+)	20,238 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24