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Try5 Gene Detail
Summary
  • Symbol
    Try5
  • Name
    trypsin 5
  • Synonyms
    1810049H19Rik, Tc
  • Feature Type
    protein coding gene
  • IDs
    MGI:102756
    NCBI Gene: 103964
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41288166-41291644 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 19.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102756
 protein coding gene Chr6:41288166-41293775 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030623
 protein coding gene Chr6:39788557-39860115 (+)
A/J MGP_AJ_G0030598
 protein coding gene Chr6:38065250-38072118 (-)
AKR/J MGP_AKRJ_G0030525
 protein coding gene Chr6:39259414-39265115 (+)
BALB/cJ MGP_BALBcJ_G0030607
 protein coding gene Chr6:38281465-38287776 (-)
C3H/HeJ MGP_C3HHeJ_G0030320
 protein coding gene Chr6:39302834-39310671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031061
 protein coding gene Chr6:40767417-40772229 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029723
 protein coding gene Chr6:39201654-39207180 (-)
CBA/J MGP_CBAJ_G0030297
 protein coding gene Chr6:42451599-42461020 (-)
DBA/2J MGP_DBA2J_G0030443
 protein coding gene Chr6:37892046-37897873 (-)
FVB/NJ MGP_FVBNJ_G0030395
 protein coding gene Chr6:37626321-37631951 (-)
LP/J MGP_LPJ_G0030530
 protein coding gene Chr6:39802085-39807375 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030433
 protein coding gene Chr6:44700150-44706254 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031090
 protein coding gene Chr6:39250267-39257684 (-)
PWK/PhJ MGP_PWKPhJ_G0029436
 protein coding gene Chr6:37511572-37515059 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029272
 protein coding gene Chr6:38950287-38956401 (-)
WSB/EiJ MGP_WSBEiJ_G0029799
 protein coding gene Chr6:39186150-39190943 (-)



Homology
more
  • Human Ortholog
    PRSS1, serine protease 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS1, serine protease 1
  • Synonyms
    TRP1, TRY1, TRY4, TRYP1
  • Links
    NCBI Gene ID: 5644
    neXtProt AC: NX_P07477
    UniProt: P07477

  • Chr Location
    7q34; chr7:142749468-142753072 (+)  GRCh38
  • Human Ortholog
    PRSS2, serine protease 2
  • Synonyms
    TRY2, TRY8, TRYP2
  • Links
    NCBI Gene ID: 5645
    neXtProt AC: NX_P07478
    UniProt: P07478

  • Chr Location
    7q34; chr7:142760398-142774564 (+)  GRCh38
  • Human Ortholog
    PRSS3, serine protease 3
  • Synonyms
    MTG, PRSS4, T9, TRY3, TRY4
  • Links
    NCBI Gene ID: 5646
    neXtProt AC: NX_P35030
    UniProt: P35030

  • Chr Location
    9p13.3; chr9:33750679-33799231 (+)  GRCh38
  • Human Ortholog
    PRSS3P2, PRSS3 pseudogene 2
  • Synonyms
    T6, TRY6
  • Links
    NCBI Gene ID: 154754
    UniProt: Q8NHM4

  • Chr Location
    7q34
Human Diseases
more
  • Diseases
    1 with human PRSS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    1
  • cDNA Data
    418
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 103964 NCBI Gene Model | MGI Sequence Detail 3479 C57BL/6J ±  kb
transcript NM_001003405 RefSeq | MGI Sequence Detail 806 C57BL/6  
polypeptide Q9QUK9 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • EC
    3.4.21.4
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
    IPR050127 Serine Proteases (Peptidase S1 Family)
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
  • GlyGen
    Q9QUK9 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 419
    Genomic 1
    cDNA 418

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-19661, MGI:3045752
References
more
  • Summaries
    All 21
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
  • Latest
    J:330316 Nemeth BC, et al., Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop. J Biol Chem. 2013 Aug 16;288(33):24049-62
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory