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Star Gene Detail
Summary
  • Symbol
    Star
  • Name
    steroidogenic acute regulatory protein
  • Synonyms
    D8Ertd419e
  • Feature Type
    protein coding gene
  • IDs
    MGI:102760
    NCBI Gene: 20845
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26298502-26306010 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 14.17 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102760
 protein coding gene Chr8:26296583-26306010 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033489
 protein coding gene Chr8:23880304-23886547 (+)
A/J MGP_AJ_G0033469
 protein coding gene Chr8:23013326-23019589 (+)
AKR/J MGP_AKRJ_G0033394
 protein coding gene Chr8:23774899-23782416 (+)
BALB/cJ MGP_BALBcJ_G0033465
 protein coding gene Chr8:23159479-23166064 (+)
C3H/HeJ MGP_C3HHeJ_G0033179
 protein coding gene Chr8:23984273-23990567 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033981
 protein coding gene Chr8:24846689-24852858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030931
 protein coding gene Chr8:20278691-20284723 (+)
CAST/EiJ MGP_CASTEiJ_G0032505
 protein coding gene Chr8:23434365-23440545 (+)
CBA/J MGP_CBAJ_G0033154
 protein coding gene Chr8:25814498-25823437 (+)
DBA/2J MGP_DBA2J_G0033309
 protein coding gene Chr8:22983349-22989690 (+)
FVB/NJ MGP_FVBNJ_G0033253
 protein coding gene Chr8:22789600-22795891 (+)
LP/J MGP_LPJ_G0033398
 protein coding gene Chr8:23858155-23864326 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033296
 protein coding gene Chr8:25273490-25279711 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034000
 protein coding gene Chr8:23707806-23714018 (+)
PWK/PhJ MGP_PWKPhJ_G0032216
 protein coding gene Chr8:22624480-22630689 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032050
 protein coding gene Chr8:23083755-23090002 (+)
WSB/EiJ MGP_WSBEiJ_G0032621
 protein coding gene Chr8:23928307-23935817 (+)



Homology
more
  • Human Ortholog
    STAR, steroidogenic acute regulatory protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAR, steroidogenic acute regulatory protein
  • Synonyms
    STARD1
  • Links
    NCBI Gene ID: 6770
    neXtProt AC: NX_P49675
    UniProt: P49675

  • Chr Location
    8p11.23; chr8:38142700-38150992 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Star mouse models; 1 with human STAR associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    3 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice fail to thrive and die during the postnatal period due to adrenocortical insufficiency. Mice exhibit male pseudohermaprhoditism and show a progressive accumulation of lipids within steroidogenic cells of the adrenal glands and gonads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    48
  • cDNA Data
    47
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20845 NCBI Gene Model | MGI Sequence Detail 7509 C57BL/6J ±  kb
    transcript NM_011485 RefSeq | MGI Sequence Detail 4046 ZRU/MplStud  
    polypeptide P51557 UniProt | EBI | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 1
      cDNA 48
      Primer pair 8
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-19665, MGI:1196454, MGI:2142741
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 66
      Diseases 3
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:21385 Clark BJ, et al., The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994 Nov 11;269(45):28314-22
    • Latest
      J:354194 Oikonomakos I, et al., In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory