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Guca1a Gene Detail
Summary
  • Symbol
    Guca1a
  • Name
    guanylate cyclase activator 1a (retina)
  • Synonyms
    Guca1, mGCAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102770
    NCBI Gene: 14913
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47705483-47711509 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.07 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102770
 protein coding gene Chr17:47705482-47724439 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023843
 protein coding gene Chr17:48536645-48542629 (-)
A/J MGP_AJ_G0023801
 protein coding gene Chr17:47335044-47341050 (-)
AKR/J MGP_AKRJ_G0023772
 protein coding gene Chr17:47714233-47720186 (-)
BALB/cJ MGP_BALBcJ_G0023805
 protein coding gene Chr17:47249647-47255596 (-)
C3H/HeJ MGP_C3HHeJ_G0023568
 protein coding gene Chr17:48463993-48469988 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024248
 protein coding gene Chr17:50602501-50608512 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021698
 protein coding gene Chr17:44090571-44097499 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0023545
 protein coding gene Chr17:52458083-52464084 (-)
DBA/2J MGP_DBA2J_G0023671
 protein coding gene Chr17:46093778-46099884 (-)
FVB/NJ MGP_FVBNJ_G0023638
 protein coding gene Chr17:45738685-45744638 (-)
LP/J MGP_LPJ_G0023752
 protein coding gene Chr17:49215160-49221113 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023667
 protein coding gene Chr17:51935861-51941850 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024293
 protein coding gene Chr17:48077913-48083867 (-)
PWK/PhJ MGP_PWKPhJ_G0022794
 protein coding gene Chr17:45453223-45459876 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022610
 protein coding gene Chr17:44976708-44982658 (-)
WSB/EiJ MGP_WSBEiJ_G0023115
 protein coding gene Chr17:48656890-48663046 (-)



Homology
more
  • Human Ortholog
    GUCA1A, guanylate cyclase activator 1A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GUCA1A, guanylate cyclase activator 1A
  • Synonyms
    C6orf131, COD3, CORD14, GCAP, GCAP-1, GCAP1, GCAP-I, GUCA, GUCA1
  • Links
    NCBI Gene ID: 2978
    neXtProt AC: NX_P43080
    UniProt: P43080

  • Chr Location
    6p21.1; chr6:42173364-42181338 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GUCA1A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 5 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous or homozygous for a knock-in allele exhibit photoreceptor degeneration and loss of cone and rod function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    43
  • cDNA Data
    34
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023982 Ensembl Gene Model | MGI Sequence Detail 6027 C57BL/6J ±  kb
    transcript ENSMUST00000059348 Ensembl | MGI Sequence Detail 873 Not Applicable  
    polypeptide ENSMUSP00000060027 Ensembl | MGI Sequence Detail 202 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 6
      cDNA 35
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19677
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 41
    • Earliest
      J:19567 Subbaraya I, et al., Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem. 1994 Dec 9;269(49):31080-9
    • Latest
      J:330334 Zhang H, et al., The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance. Development. 2022 Oct 1;149(19):dev200497
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory