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Rab18 Gene Detail
Summary
  • Symbol
    Rab18
  • Name
    RAB18, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:102790
    NCBI Gene: 19330
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:6765167-6791606 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 4.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    643 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102790
 protein coding gene Chr18:6733905-6794429 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024132
 protein coding gene Chr18:3665194-3690189 (+)
A/J MGP_AJ_G0024094
 protein coding gene Chr18:3675771-3700843 (+)
AKR/J MGP_AKRJ_G0024062
 protein coding gene Chr18:3754245-3779088 (+)
BALB/cJ MGP_BALBcJ_G0024094
 protein coding gene Chr18:3633180-3658102 (+)
C3H/HeJ MGP_C3HHeJ_G0023860
 protein coding gene Chr18:3648831-3673863 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024539
 protein coding gene Chr18:3916904-3941939 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021978
 protein coding gene Chr18:3405268-3432477 (+)
CAST/EiJ MGP_CASTEiJ_G0023338
 protein coding gene Chr18:3652992-3682669 (+)
CBA/J MGP_CBAJ_G0023833
 protein coding gene Chr18:3823854-3848878 (+)
DBA/2J MGP_DBA2J_G0023961
 protein coding gene Chr18:3527562-3556757 (+)
FVB/NJ MGP_FVBNJ_G0023927
 protein coding gene Chr18:3529881-3555159 (+)
LP/J MGP_LPJ_G0024045
 protein coding gene Chr18:3683510-3709356 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023955
 protein coding gene Chr18:3928583-3955183 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024584
 protein coding gene Chr18:3614766-3640006 (+)
PWK/PhJ MGP_PWKPhJ_G0023083
 protein coding gene Chr18:3591547-3615227 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022894
 protein coding gene Chr18:3899033-3926661 (+)
WSB/EiJ MGP_WSBEiJ_G0023404
 protein coding gene Chr18:3652471-3679979 (+)



Homology
more
  • Human Ortholog
    RAB18, RAB18, member RAS oncogene family
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB18, RAB18, member RAS oncogene family
  • Synonyms
    RAB18LI1, WARBM3
  • Links
    NCBI Gene ID: 22931
    neXtProt AC: NX_Q9NP72
    UniProt: Q9NP72

  • Chr Location
    10p12.1; chr10:27504174-27543207 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rab18 mouse models; 1 with human RAB18 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show partial perinatal lethality and abnormal eye development, and develop nuclear cataracts, atonic pupils, progressive limb weakness, disruption of neuronal cytoskeleton, and accumulation of neurofilament and microtubule proteins in synaptic terminals.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    59
  • cDNA Data
    192
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19330 NCBI Gene Model | MGI Sequence Detail 26440 C57BL/6J ±  kb
    transcript NM_001278447 RefSeq | MGI Sequence Detail 3688 ZRU/MplStud  
    polypeptide P35293 UniProt | EBI | MGI Sequence Detail 206 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 194
      cDNA 193
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19698, MGI:2147186
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory