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Fstl1 Gene Detail
Summary
  • Symbol
    Fstl1
  • Name
    follistatin-like 1
  • Synonyms
    TSC-36
  • Feature Type
    protein coding gene
  • IDs
    MGI:102793
    NCBI Gene: 14314
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:37597417-37656878 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.48 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1671 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102793
 protein coding gene Chr16:37597235-37656878 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022804
 protein coding gene Chr16:36263501-36323636 (+)
A/J MGP_AJ_G0022769
 protein coding gene Chr16:34455762-34516559 (+)
AKR/J MGP_AKRJ_G0022741
 protein coding gene Chr16:35774745-35841838 (+)
BALB/cJ MGP_BALBcJ_G0022770
 protein coding gene Chr16:34583155-34642248 (+)
C3H/HeJ MGP_C3HHeJ_G0022534
 protein coding gene Chr16:35886478-35945805 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023217
 protein coding gene Chr16:37111802-37173461 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020731
 protein coding gene Chr16:34844912-34900485 (+)
CAST/EiJ MGP_CASTEiJ_G0022060
 protein coding gene Chr16:36024115-36102963 (+)
CBA/J MGP_CBAJ_G0022505
 protein coding gene Chr16:38726248-38791342 (+)
DBA/2J MGP_DBA2J_G0022637
 protein coding gene Chr16:34351413-34409815 (+)
FVB/NJ MGP_FVBNJ_G0022612
 protein coding gene Chr16:34382947-34439684 (+)
LP/J MGP_LPJ_G0022705
 protein coding gene Chr16:35951995-36011902 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022631
 protein coding gene Chr16:37874349-37938087 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023232
 protein coding gene Chr16:35729892-35791412 (+)
PWK/PhJ MGP_PWKPhJ_G0021800
 protein coding gene Chr16:34755334-34825594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021631
 protein coding gene Chr16:35647962-35706603 (+)
WSB/EiJ MGP_WSBEiJ_G0022104
 protein coding gene Chr16:35808633-35866857 (+)



Homology
more
  • Human Ortholog
    FSTL1, follistatin like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FSTL1, follistatin like 1
  • Synonyms
    FRP, FSL1, MIR198, OCC-1, OCC1, tsc36
  • Links
    NCBI Gene ID: 11167
    neXtProt AC: NX_Q12841
    UniProt: Q12841

  • Chr Location
    3q13.33; chr3:120392293-120451016 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fstl1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotypes from 10 alleles in 10 genetic backgrounds
    6 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, soft and enlarged trachea, cyanosis, primary atelectasis, lung epithelial cell hyperplasia, over-expanded bronchiole, impaired pneumocyte differentiation and maturation, and decreased surfactant production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1288
  • Tissues
    255
  • cDNA Data
    18
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14314 NCBI Gene Model | MGI Sequence Detail 59462 C57BL/6J ±  kb
    transcript NM_008047 RefSeq | MGI Sequence Detail 3609 ZRU/MplStud  
    polypeptide Q62356 UniProt | EBI | MGI Sequence Detail 306 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 19
      Primer pair 6
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-19701, MGI:2146409, MGI:2146619
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 32
      Diseases 1
      Gene Ontology 6
      Phenotypes 42
    • Earliest
      J:15692 Shibanuma M, et al., Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide. Eur J Biochem. 1993 Oct 1;217(1):13-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory