About   Help   FAQ
Fgl1 Gene Detail
Summary
  • Symbol
    Fgl1
  • Name
    fibrinogen-like protein 1
  • Synonyms
    MGC:37822
  • Feature Type
    protein coding gene
  • IDs
    MGI:102795
    NCBI Gene: 234199
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:41644471-41668193 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    828 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102795
 protein coding gene Chr8:41644471-41671015 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033560
 protein coding gene Chr8:40028132-40050990 (-)
A/J MGP_AJ_G0033543
 protein coding gene Chr8:38504097-38526964 (-)
AKR/J MGP_AKRJ_G0033466
 protein coding gene Chr8:39667133-39690024 (-)
BALB/cJ MGP_BALBcJ_G0033538
 protein coding gene Chr8:38626197-38649064 (-)
C3H/HeJ MGP_C3HHeJ_G0033248
 protein coding gene Chr8:40057297-40080882 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034054
 protein coding gene Chr8:41543420-41571687 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031003
 protein coding gene Chr8:35157045-35182206 (-)
CAST/EiJ MGP_CASTEiJ_G0032576
 protein coding gene Chr8:39552369-39578222 (-)
CBA/J MGP_CBAJ_G0033226
 protein coding gene Chr8:43260086-43282981 (-)
DBA/2J MGP_DBA2J_G0033380
 protein coding gene Chr8:38335800-38358668 (-)
FVB/NJ MGP_FVBNJ_G0033324
 protein coding gene Chr8:37919047-37941938 (-)
LP/J MGP_LPJ_G0033469
 protein coding gene Chr8:40063441-40086302 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033366
 protein coding gene Chr8:43015345-43038455 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034072
 protein coding gene Chr8:39819810-39842671 (-)
PWK/PhJ MGP_PWKPhJ_G0032285
 protein coding gene Chr8:37882245-37909233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032117
 protein coding gene Chr8:38986981-39013149 (-)
WSB/EiJ MGP_WSBEiJ_G0032691
 protein coding gene Chr8:40027069-40049900 (-)



Homology
more
  • Human Ortholog
    FGL1, fibrinogen like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGL1, fibrinogen like 1
  • Synonyms
    HFREP1, HP-041, HPS, LFIRE-1, LFIRE1
  • Links
    NCBI Gene ID: 2267
    neXtProt AC: NX_Q08830
    UniProt: Q08830

  • Chr Location
    8p22; chr8:17864380-17910365 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit increased body weight, white fat and gluconeogenesis, decreased circulating cholesterol, free fatty acid level and respiratory quotient, hyperglycemia, and impaired glucose tolerance. Mice homozygous for a second null allele display normal appearance with age-related onset of dermatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    6
  • cDNA Data
    31
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031594 Ensembl Gene Model | MGI Sequence Detail 23723 C57BL/6J ±  kb
    transcript ENSMUST00000034003 Ensembl | MGI Sequence Detail 1120 Not Applicable  
    polypeptide ENSMUSP00000034003 Ensembl | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007508 fibrinogen-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR037579 Fibrinogen
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR020837 Fibrinogen, conserved site
      IPR050373 Fibrinogen C-terminal domain-containing protein
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-19703
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:23981 Yamamoto T, et al., Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. Biochem Biophys Res Commun. 1993 Jun 15;193(2):681-7
    • Latest
      J:346534 Sardo U, et al., The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling. Blood. 2024 Mar 28;143(13):1282-1292
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory